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Polysaccharides: Synthesis, Properties and Applications—2nd Edition

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 1174

Special Issue Editors


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Guest Editor
CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China
Interests: polysaccharides; starch; structure–property relationships; supramolecular structures; starch modification
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China
Interests: marine functional polysaccharide; glycosaminoglycan; anticoagulant polysaccharide; glycoprotein; polysaccharide biosynthesis and biotransformation; marine drug; functional food
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
Interests: chitin; polysaccharide derivatization; carbohydrate chemistry; agrochemicals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I am pleased to invite you to contribute to the Special Issue entitled “Polysaccharides: Synthesis, Properties and Applications—2nd Edition”. This Special Issue will showcase the latest advancements and innovations in the field of polysaccharide research, from fundamental understanding to practical applications. The unique properties of polysaccharides, such as biocompatibility and biodegradability, have made them attractive materials in the development of novel functional and smart systems. We welcome original research articles and reviews on a range of topics including, but not limited to, the following:

  • Novel synthesis and extraction methods for polysaccharides;
  • Chemical, enzymatic and physical modifications of polysaccharides;
  • Structure–property relationships of polysaccharides and their derivatives;
  • Polysaccharide-based nanomaterials, hydrogels and composites;
  • Biomedical applications of polysaccharides, such as drug delivery, tissue engineering and wound healing;
  • Polysaccharides in food, cosmetics and personal care products;
  • Polysaccharide-based materials for environmental remediation and water treatment;
  • Advances in characterization techniques for polysaccharides.

Dr. Guantian Li
Dr. Rongfeng Li
Dr. Kun Gao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polysaccharides
  • synthesis
  • extraction methods
  • modifications
  • characterizations
  • structure–property relationships
  • applications
  • nanocomposites
  • biomaterials

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Related Special Issue

Published Papers (2 papers)

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Research

15 pages, 5720 KB  
Article
Ultrasonic-Assisted Hot-Water Extraction Optimization, Preliminary Characterization and Antioxidant Activity of Polysaccharides from Zingiber striolatum
by Yanan Wang, Ling Yang, Xinyi Qian, Yihao Li, Hao Zhang, Yuhan Yang, Aliyu Lawal, Zaizhong Ni, Lulu Li, Zhe Wang, Ying Shao and Anhui Chen
Polymers 2026, 18(4), 498; https://doi.org/10.3390/polym18040498 - 17 Feb 2026
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Abstract
Polysaccharides serve as the main bioactive compounds of Zingiber striolatum (Z. striolatum). However, their structures and functions require further research. The present work used response surface methodology (RSM) for optimizing polysaccharide extraction conditions from Z. striolatum through ultrasonic-assisted hot-water extraction and [...] Read more.
Polysaccharides serve as the main bioactive compounds of Zingiber striolatum (Z. striolatum). However, their structures and functions require further research. The present work used response surface methodology (RSM) for optimizing polysaccharide extraction conditions from Z. striolatum through ultrasonic-assisted hot-water extraction and evaluating the antioxidant properties of Z. striolatum polysaccharides. According to our findings, optimal Z. striolatum polysaccharide extraction conditions included ultrasonic power of 200 W, extraction temperature of 79 °C, extraction duration of 2.5 h, and ultrasonic time of 20 min, with the extraction yield reached 19.96% ± 0.18%. The molecular weight (MW) of the purified polysaccharide ZS-P1-1 isolated from Z. striolatum was 5.63 × 104 kDa, mainly composed of galactose (Gal), galacturonic acid (GalA) and glucuronic acid (GlcA) in a 0.453:0.162:0.114 molar ratio. Typically, 2,2-diphenyl-1-picrylhydrazyl radical (DPPH·) and hydroxyl radical (·OH) scavenging capacities and total reducing ability reached 30.49% ± 1.82%, 28.51% ± 1.40% and 0.64 ± 0.07 of ZS-P1-1 at 0.5 mg/mL, respectively. Moreover, ZS-P1-1 increased the reduced glutathione (GSH) level, enhanced the total superoxide dismutase (T-SOD), reduced the malondialdehyde (MDA) level, and alleviated the liver and kidney damage caused by oxidative stress in mice. Our results suggest that ZS-P1-1 shows excellent antioxidant properties and provides a certain theoretical foundation for developing and utilizing Z. striolatum polysaccharides. Full article
(This article belongs to the Special Issue Polysaccharides: Synthesis, Properties and Applications—2nd Edition)
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16 pages, 1563 KB  
Article
Ultrasound-Assisted Extraction of Adenophora triphylla Polysaccharides: Optimization and Characterization of Physicochemical and Functional Properties
by Hye-In Lee, Ha-Seong Cho, Ju-Hwi Park, Ju-Ock Nam, Hyun-Mo Jung, Myung-Hee Lee and Won-Young Lee
Polymers 2026, 18(4), 457; https://doi.org/10.3390/polym18040457 - 11 Feb 2026
Viewed by 503
Abstract
In this study, ultrasound-assisted extraction (UAE) of Adenophora triphylla root polysaccharides (ATRPs) was optimized using response surface methodology (RSM), and the physicochemical and functional properties of the resulting polysaccharides were investigated. A Box–Behnken Design (BBD) was applied to optimize the UAE conditions for [...] Read more.
In this study, ultrasound-assisted extraction (UAE) of Adenophora triphylla root polysaccharides (ATRPs) was optimized using response surface methodology (RSM), and the physicochemical and functional properties of the resulting polysaccharides were investigated. A Box–Behnken Design (BBD) was applied to optimize the UAE conditions for ATRPs. The optimal UAE conditions for ATRPs with the maximum extraction yield were an extraction temperature of 34 °C, an extraction time of 41 min, and a solvent-to-solid ratio of 34 (mL/g). Under these conditions, the maximum extraction yield of UAE-ATRPs (12.46%) was significantly higher than that obtained by water extraction without sonication (WE-ATRPs, 9.76%). The results of monosaccharide composition showed that WE-ATRPs and UAE-ATRPs were heteropolysaccharides, mainly composed of glucose. In addition, FT-IR and 1H-NMR analyses indicated that both ATRPs had α-pyranose-type glycosidic structures. The optimal UAE process reduced the glucose content from 57.70% to 53.87% relative to WE-ATRPs. Moreover, UAE-ATRPs exhibited lower solution viscosity and improved the emulsifying properties relative to WE-ATRPs. Both ATRPs also exhibited anti-inflammatory activity by inhibiting nitric oxide synthesis. In summary, our findings suggest that UAE is an effective approach for improving the extraction yield and functional properties of ATRPs, highlighting their potential applications in the food industry. Full article
(This article belongs to the Special Issue Polysaccharides: Synthesis, Properties and Applications—2nd Edition)
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