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Polymers
Special Issues
Biomaterials for Tissue Engineering and Regeneration II
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Biomaterials for Tissue Engineering and Regeneration II

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 8394

Special Issue Editors

Dr. Antonia Ressler

E-Mail Website
Guest Editor
Faculty of Engineering and Natural Sciences, Tampere University, P. O. Box 589, 33014 Tampere, Finland
Interests: biodegradable polymers; biomaterials; chitosan; hydroxyapatite; scaffolds; ionic substitution; stem cells; tissue engineering and regeneration
Special Issues, Collections and Topics in MDPI journals
Dr. Inga Urlic

E-Mail Website
Guest Editor
Faculty of Science, University of Zagreb, Horvatovac 102a, 10 000 Zagreb, Croatia
Interests: cancer biology; stem cells; drug delivery; scaffolds; tissue engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Due to the success of the Special Issue “Biomaterials for Tissue Engineering and Regeneration”, a second Special Issue named “Biomaterials for Tissue Engineering and Regeneration II” is now open to submissions.

Biomaterials are an integral component of tissue engineering, and their development is crucial to the progress of new and efficient approaches in the regenerative medicine of bone, cartilage, tendons and ligaments, skin, soft-tissue wounds, cardiac muscle, vascular tissues, and neural tissues.

Polymer-based biomaterials are extensively studied in the field of tissue engineering due to their biocompatible and biodegradable properties. This Special Issue is devoted to recent developments of synthetic and/or natural biomaterial scaffolds, hydrogels, polypeptides, polymer-based composites, and composites based on polymers and inorganic materials, such as bioactive ceramics and glasses. New technologies (e.g., bioprinting, additive manufacturing) used to form biomaterials for tissue engineering of three-dimensional (3D) constructs are of particular interest.

The scope of this Special Issue includes (but is not limited to):

  • Three-dimensional polymer-based scaffolds;
  • Structure–property relationships of polymeric and composite biomaterials;
  • In vitro and in vivo biodegradability, biocompatibility, anticancer, and antibacterial properties;
  • Polymers for tissue engineering and regeneration;
  • Stem cell engineering;
  • Drug delivery (e.g., solid lipid nanoparticles, hydrogels);
  • New technologies for scaffold formation (3D fabrication).

Improvements in the field of tissue regeneration rely on the contributions of experts from various fields, such as materials science, polymer science, mechanical engineering, biomaterials, cell biology, nanotechnology, immunology, etc. For this Special Issue, we encourage scientists from different fields to submit original research and review articles.

Dr. Antonia Ressler
Dr. Inga Urlic
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biodegradable polymers
  • biomaterials
  • bioprinting
  • hydrogels
  • scaffolds
  • stem cells
  • tissue engineering

Published Papers (4 papers)

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Research

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21 pages, 9470 KiB  
Article
Topographically and Chemically Enhanced Textile Polycaprolactone Scaffolds for Tendon and Ligament Tissue Engineering
by Benedict Bauer, Caroline Emonts, Johannes Pitts, Eva Miriam Buhl, Jörg Eschweiler, Robert Hänsch, Marcel Betsch, Thomas Gries and Henning Menzel
Polymers 2024, 16(4), 488; https://doi.org/10.3390/polym16040488 - 9 Feb 2024
Viewed by 922
Abstract
The use of tissue engineering to address the shortcomings of current procedures for tendons and ligaments is promising, but it requires a suitable scaffold that meets various mechanical, degradation-related, scalability-related, and biological requirements. Macroporous textile scaffolds made from appropriate fiber material have the [...] Read more.
The use of tissue engineering to address the shortcomings of current procedures for tendons and ligaments is promising, but it requires a suitable scaffold that meets various mechanical, degradation-related, scalability-related, and biological requirements. Macroporous textile scaffolds made from appropriate fiber material have the potential to fulfill the first three requirements. This study aimed to investigate the biocompatibility, sterilizability, and functionalizability of a multilayer braided scaffold. These macroporous scaffolds with dimensions similar to those of the human anterior cruciate ligament consist of fibers with appropriate tensile strength and degradation behavior melt-spun from Polycaprolactone (PCL). Two different cross-sectional geometries resulting in significantly different specific surface areas and morphologies were used at the fiber level, and a Chitosan-graft-PCL (CS-g-PCL) surface modification was applied to the melt-spun substrates for the first time. All scaffolds elicited a positive cell response, and the CS-g-PCL modification provided a platform for incorporating functionalization agents such as drug delivery systems for growth factors, which were successfully released in therapeutically effective quantities. The fiber geometry was found to be a variable that could be manipulated to control the amount released. Therefore, scaled, surface-modified textile scaffolds are a versatile technology that can successfully address the complex requirements of tissue engineering for ligaments and tendons, as well as other structures. Full article
(This article belongs to the Special Issue Biomaterials for Tissue Engineering and Regeneration II)
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14 pages, 2721 KiB  
Article
Functionalised Hybrid Collagen-Elastin for Acellular Cutaneous Substitute Applications
by Nurkhuzaiah Kamaruzaman, Mh Busra Fauzi, Yasuhiko Tabata and Salma Mohamad Yusop
Polymers 2023, 15(8), 1929; https://doi.org/10.3390/polym15081929 - 18 Apr 2023
Cited by 2 | Viewed by 1403
Abstract
Wound contracture, which commonly happens after wound healing, may lead to physical distortion, including skin constriction. Therefore, the combination of collagen and elastin as the most abundant extracellular matrix (ECM) skin matrices may provide the best candidate biomaterials for cutaneous wound injury. This [...] Read more.
Wound contracture, which commonly happens after wound healing, may lead to physical distortion, including skin constriction. Therefore, the combination of collagen and elastin as the most abundant extracellular matrix (ECM) skin matrices may provide the best candidate biomaterials for cutaneous wound injury. This study aimed to develop a hybrid scaffold containing green natural resources (ovine tendon collagen type-I and poultry-based elastin) for skin tissue engineering. Briefly, freeze-drying was used to create the hybrid scaffolds, which were then crosslinked with 0.1% (w/v) genipin (GNP). Next, the physical characteristics (pore size, porosity, swelling ratio, biodegradability and mechanical strength) of the microstructure were assessed. Energy dispersive X-ray spectroscopy (EDX) and Fourier transform infrared (FTIR) spectrophotometry were used for the chemical analysis. The findings showed a uniform and interconnected porous structure with acceptable porosity (>60%) and high-water uptake capacity (>1200%), with pore sizes ranging between 127 ± 22 and 245 ± 35 µm. The biodegradation rate of the fabricated scaffold containing 5% elastin was lower (<0.043 mg/h) compared to the control scaffold (collagen only; 0.085 mg/h). Further analysis with EDX identified the main elements of the scaffold: it contained carbon (C) 59.06 ± 1.36–70.66 ± 2.89%, nitrogen (N) 6.02 ± 0.20–7.09 ± 0.69% and oxygen (O) 23.79 ± 0.65–32.93 ± 0.98%. FTIR analysis revealed that collagen and elastin remained in the scaffold and exhibited similar functional amides (amide A: 3316 cm−1, amide B: 2932 cm−1, amide I: 1649 cm−1, amide II: 1549 cm−1 and amide III: 1233 cm−1). The combination of elastin and collagen also produced a positive effect via increased Young’s modulus values. No toxic effect was identified, and the hybrid scaffolds significantly supported human skin cell attachment and viability. In conclusion, the fabricated hybrid scaffolds demonstrated optimum physicochemical and mechanical properties and may potentially be used as an acellular skin substitute in wound management. Full article
(This article belongs to the Special Issue Biomaterials for Tissue Engineering and Regeneration II)
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Review

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36 pages, 1796 KiB  
Review
An Overview of Scaffolds and Biomaterials for Skin Expansion and Soft Tissue Regeneration: Insights on Zinc and Magnesium as New Potential Key Elements
by Nourhan Hassan, Thomas Krieg, Max Zinser, Kai Schröder and Nadja Kröger
Polymers 2023, 15(19), 3854; https://doi.org/10.3390/polym15193854 - 22 Sep 2023
Cited by 4 | Viewed by 2281
Abstract
The utilization of materials in medical implants, serving as substitutes for non-functional biological structures, supporting damaged tissues, or reinforcing active organs, holds significant importance in modern healthcare, positively impacting the quality of life for millions of individuals worldwide. However, certain implants may only [...] Read more.
The utilization of materials in medical implants, serving as substitutes for non-functional biological structures, supporting damaged tissues, or reinforcing active organs, holds significant importance in modern healthcare, positively impacting the quality of life for millions of individuals worldwide. However, certain implants may only be required temporarily to aid in the healing process of diseased or injured tissues and tissue expansion. Biodegradable metals, including zinc (Zn), magnesium (Mg), iron, and others, present a new paradigm in the realm of implant materials. Ongoing research focuses on developing optimized materials that meet medical standards, encompassing controllable corrosion rates, sustained mechanical stability, and favorable biocompatibility. Achieving these objectives involves refining alloy compositions and tailoring processing techniques to carefully control microstructures and mechanical properties. Among the materials under investigation, Mg- and Zn-based biodegradable materials and their alloys demonstrate the ability to provide necessary support during tissue regeneration while gradually degrading over time. Furthermore, as essential elements in the human body, Mg and Zn offer additional benefits, including promoting wound healing, facilitating cell growth, and participating in gene generation while interacting with various vital biological functions. This review provides an overview of the physiological function and significance for human health of Mg and Zn and their usage as implants in tissue regeneration using tissue scaffolds. The scaffold qualities, such as biodegradation, mechanical characteristics, and biocompatibility, are also discussed. Full article
(This article belongs to the Special Issue Biomaterials for Tissue Engineering and Regeneration II)
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22 pages, 4238 KiB  
Review
Progress in Biomaterials for Cardiac Tissue Engineering and Regeneration
by Alexandru Scafa Udriște, Adelina-Gabriela Niculescu, Luminița Iliuță, Teodor Bajeu, Adriana Georgescu, Alexandru Mihai Grumezescu and Elisabeta Bădilă
Polymers 2023, 15(5), 1177; https://doi.org/10.3390/polym15051177 - 26 Feb 2023
Cited by 7 | Viewed by 3196
Abstract
Cardiovascular diseases are one of the leading global causes of morbidity and mortality, posing considerable health and economic burden on patients and medical systems worldwide. This phenomenon is attributed to two main motives: poor regeneration capacity of adult cardiac tissues and insufficient therapeutic [...] Read more.
Cardiovascular diseases are one of the leading global causes of morbidity and mortality, posing considerable health and economic burden on patients and medical systems worldwide. This phenomenon is attributed to two main motives: poor regeneration capacity of adult cardiac tissues and insufficient therapeutic options. Thus, the context calls for upgrading treatments to deliver better outcomes. In this respect, recent research has approached the topic from an interdisciplinary perspective. Combining the advances encountered in chemistry, biology, material science, medicine, and nanotechnology, performant biomaterial-based structures have been created to carry different cells and bioactive molecules for repairing and restoring heart tissues. In this regard, this paper aims to present the advantages of biomaterial-based approaches for cardiac tissue engineering and regeneration, focusing on four main strategies: cardiac patches, injectable hydrogels, extracellular vesicles, and scaffolds and reviewing the most recent developments in these fields. Full article
(This article belongs to the Special Issue Biomaterials for Tissue Engineering and Regeneration II)
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