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Pharmaceutics
Special Issues
Advances in Amorphous Solid Dispersions
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Advances in Amorphous Solid Dispersions

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 1114

Special Issue Editor

Dr. Natalia Rosiak

E-Mail Website
Guest Editor
Department of Pharmacognosy and Biomaterials, Faculty of Pharmacy, Poznan University of Medical Sciences, 3 Rokietnicka St., 60-806 Poznan, Poland
Interests: amorphous solid dispersion; FT-IR; molecular docking; drug delivery; polyphenols; data analysis

Special Issue Information

Dear Colleagues,

This Special Issue, entitled "Advances in Amorphous Solid Dispersions", aims at highlighting the latest developments in the formulation and application of amorphous solid dispersions (ASDs) in the pharmaceutical sciences. ASDs have become a crucial approach to enhance the solubility and bioavailability of poorly water-soluble drugs, addressing a major challenge in drug development. By converting crystalline drugs into amorphous forms, ASDs can significantly improve dissolution rates and therapeutic effectiveness.

The importance of ASDs lies in their potential to optimize oral dosage forms and improve patient outcomes. Recent innovations in materials, formulation techniques, and characterization methods have led to the development of more stable and efficient ASD formulations.

We invite original research articles and review papers that explore novel methodologies, the use of theoretical research, stability investigations, formulation strategies, and innovative applications of ASDs. Contributions that address challenges in the formulation, processing, and characterization of amorphous solid dispersions are particularly welcome. Through this Special Issue, we aim at fostering collaboration and stimulating discussions among researchers and industry professionals to advance the understanding and application of ASDs in enhancing drug delivery systems.

I look forward to receiving your contributions.

Dr. Natalia Rosiak
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • amorphous solid dispersions
  • solubility enhancement
  • bioavailability
  • hot melt extrusion
  • ball milling
  • spray drying
  • freeze-drying
  • drug–polymer interactions
  • stability
  • pharmaceutical formulations

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Published Papers (1 paper)

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Research

22 pages, 7505 KB  
Article
Impact of Different Surfactants on Oral Bioavailability of Paclitaxel/HPMC-AS Amorphous Solid Dispersion
by Chenzhao Zhang, Siyi Mao, Jinhua Yuan, Xiuzhen Ma, Aiya Xing, Xiaoling Liu and Yuejie Chen
Pharmaceutics 2025, 17(11), 1487; https://doi.org/10.3390/pharmaceutics17111487 - 18 Nov 2025
Viewed by 568
Abstract
Objectives: Surfactants are commonly incorporated into amorphous solid dispersions (ASDs) to improve manufacturing and enhance the dissolution of poorly water-soluble drugs. However, their impact on in vitro dissolution, in vivo bioavailability, and in vitro-in vivo correlation (IVIVC) remains poorly understood, impeding the rational [...] Read more.
Objectives: Surfactants are commonly incorporated into amorphous solid dispersions (ASDs) to improve manufacturing and enhance the dissolution of poorly water-soluble drugs. However, their impact on in vitro dissolution, in vivo bioavailability, and in vitro-in vivo correlation (IVIVC) remains poorly understood, impeding the rational design of ASDs. This study aimed to elucidate the impact of six surfactants: anionic sodium lauroyl glutamate (SLG), sodium taurocholate (NaTC), sodium lauryl sulfate (SLS), and non-ionic polysorbate 80 (TW80), poloxamer 188 (P188), and polyoxyethylene lauryl ether (Brij-35), on the performance of paclitaxel (PTX)/HPMC-AS ASD. Methods: Binary PTX/HPMC-AS and ternary PTX/HPMC-AS/surfactant ASDs were prepared via rotary evaporation for FT-IR study. For dissolution and pharmacokinetic studies, low drug-loading formulations were prepared by physically blending PTX/HPMC-AS ASD with surfactants. Drug–polymer–surfactant interactions were investigated using NMR and FT-IR techniques. Dissolution performance was systematically evaluated by analyzing: (1) solubility of crystalline PTX in HPMC-AS/surfactant solutions; (2) supersaturation sustaining capacity in HPMC-AS/surfactant solutions; (3) surfactant effects on ASD dissolution and supersaturation generation; and (4) phase transformation during ASD dissolution. In vivo bioavailability was assessed in rats. Results: Findings revealed surfactant-specific effects: (1) SLG and P188 minimally affected bioavailability of PTX/HPMC-AS ASD (p > 0.05), consistent with their negligible effect on dissolution, attributable to incompatibility with PTX/HPMC-AS and weak molecular interactions; (2) TW80 significantly reduced bioavailability (p < 0.001) by inducing crystallization; thereby diminishing the amorphous advantage; (3) NaTC, Brij-35, and SLS markedly increased bioavailability (p < 0.001), owing to their compatibility with PTX and HPMC-AS, which enhanced dissolution and maintained amorphous state of precipitates. Surfactants appear to modulate ASD performance by governing supersaturation generation in solution and maintaining amorphous stability in the undissolved solid. Conclusions: The dissolution and bioavailability of ASDs are fundamentally controlled by compatibility between drug, polymer, and surfactant. Surfactant selection critically impacts ASD bioavailability. Comprehensive dissolution characterization, including supersaturation kinetics and precipitate phase analysis, enables prediction of bioavailability. Integrating molecular-level interaction analysis with multidimensional dissolution profiling is therefore essential for rational ASD design. Full article
(This article belongs to the Special Issue Advances in Amorphous Solid Dispersions)
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