Smart Nanocarriers for Drug Delivery in Colon Cancer

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (20 April 2023) | Viewed by 3072

Special Issue Editors


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Departamento de Ingeniería Química y Textil, Universidad de Salamanca, Pl/La Merced s/n, 37008 Salamanca, Spain
Interests: nanomedicine; nanotechnology; nanomaterials; targeted drug delivery
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Section of Immunobiology, University of León, Campus de Vegazana s/n, 24071 León, Spain
Interests: nanomedicine; nanotechnology; nanomaterials; targeted drug delivery
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Department of Analytical Chemistry, Physical Chemistry and Chemical Engineering, Pza. San Diego, s/n, 28801 Alcalá de Henares, Spain
Interests: nanomedicine; nanotechnology; nanomaterials; targeted drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Despite advances in the diagnosis and treatment of colorectal cancer, its incidence is increasing at an alarming rate, and it is currently the third most common cause of cancer-related death worldwide. As with most solid tumors, one of the most challenging issues in colon cancer therapy is associated with the severe side toxicity of chemotherapeutic drugs. Thus, there is an urgent need to reproducibly develop effective targeted nanocarriers capable of preventing drug adsorption and degradation in the upper gastrointestinal tract, and thus capable of transporting chemotherapeutic drugs to the colon.

This Special Issue aims to collect recent trends in the field of colon cancer therapy related to the use of nanocarriers capable of promoting active targeting in the tumor microenvironment. Thus, we welcome articles on the development, characterization and validation of liposomes, nanoparticles, nanohydrogels and nanocomposites conjugated with selective targeting molecules and/or stimuli-responsive, designed to improve the main drawbacks of traditional chemotherapy. 

Dr. Milena A. Vega
Dr. Celia Nieto
Dr. Gema Marcelo
Guest Editors

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Keywords

  • liposomes and lipid-based formulations
  • polymeric and metal nanoparticles
  • hydrogels and nanocomposites
  • targeted drug delivery
  • smart drug delivery
  • controlled drug release
  • nanomaterial functionalization

Published Papers (1 paper)

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21 pages, 2089 KiB  
Review
Dendrimer-Mediated Delivery of Anticancer Drugs for Colon Cancer Treatment
by Divya Bharti Rai, Kanakaraju Medicherla, Deep Pooja and Hitesh Kulhari
Pharmaceutics 2023, 15(3), 801; https://doi.org/10.3390/pharmaceutics15030801 - 1 Mar 2023
Cited by 8 | Viewed by 2707
Abstract
The third most common cancer worldwide is colon cancer (CC). Every year, there more cases are reported, yet there are not enough effective treatments. This emphasizes the need for new drug delivery strategies to increase the success rate and reduce side effects. Recently, [...] Read more.
The third most common cancer worldwide is colon cancer (CC). Every year, there more cases are reported, yet there are not enough effective treatments. This emphasizes the need for new drug delivery strategies to increase the success rate and reduce side effects. Recently, a lot of trials have been done for developing natural and synthetic medicines for CC, among which the nanoparticle-based approach is the most trending. Dendrimers are one of the most utilized nanomaterials that are accessible and offer several benefits in the chemotherapy-based treatment of CC by improving the stability, solubility, and bioavailability of drugs. They are highly branched polymers, making it simple to conjugate and encapsulate medicines. Dendrimers have nanoscale features that enable the differentiation of inherent metabolic disparities between cancer cells and healthy cells, enabling the passive targeting of CC. Moreover, dendrimer surfaces can be easily functionalized to improve the specificity and enable active targeting of colon cancer. Therefore, dendrimers can be explored as smart nanocarriers for CC chemotherapy. Full article
(This article belongs to the Special Issue Smart Nanocarriers for Drug Delivery in Colon Cancer)
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