Special Issue "Additive Manufacturing Approaches to Produce Drug Delivery Systems Volume II"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 786

Special Issue Editors

Dr. Joana Valente
E-Mail Website
Guest Editor
Centre for Rapid and Sustainable Product Development, Polytechnic Institute of Leiria, 2430-028 Leiria, Portugal
Interests: additive manufacturing; antimicrobial materials; biomaterials; chromatography; drug delivery systems; gene therapy; tissue engineering
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Nuno Alves
E-Mail Website
Guest Editor
Polytechnic Institute of Leiria, Centre for Rapid and Sustainable Product Development, Leiria, Portugal
Interests: additive manufacturing; biomimetics and bioinspiration; computer-aided engineering; computer-aided manufacturing; multi-material 3D/4D structures; industrial/biomedical applications; tissue engineering; mould design and polymer injection moulding; circular economy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, additive manufacturing approaches have provided innovative and cutting-edge technologies that have significantly improved different fields. One of the applications of these methodologies is the production of enhanced drug delivery systems. In this regard, using these technologies enables the full manipulation of several drug delivery production parameters that are not able to be changed/combined when conventional approaches are used. Among these parameters are the porosity, layer and piece dimensions (from nanometres to the desirable), interconnectivity and mono- or multi-material production. Currently, the structures produced through additive manufacturing include scaffolds used on hard tissue regeneration, wound dressings made by fibres that can perfectly mimic the soft tissue and nanometric structures that can be used for transdermal medication. All these kinds of structures could be filled with drugs and biochemical markers leading to a quick and successful therapeutic process.

The potential topics for this Special Issue include, but are not limited to, the following:

  • Medicines (oral, rectal and vaginal);
  • Intravenous and transdermal approaches;
  • Scaffolds and wound dressings;
  • Additive manufacturing technologies for drug delivery systems;
  • Drug delivery mathematical models.

Dr. Joana Valente
Prof. Dr. Nuno Alves
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • additive manufacturing
  • drug delivery systems
  • scaffolds
  • wound dressings
  • intravenous and transdermal approaches
  • biomaterials
  • drug delivery mathematical models

Published Papers (1 paper)

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Research

Article
Implementation of a New Electronic Liquid Dispensing System for Individualized Compounding of Hard Capsules
Pharmaceutics 2022, 14(8), 1580; https://doi.org/10.3390/pharmaceutics14081580 - 29 Jul 2022
Viewed by 411
Abstract
An automated compounding device can be a useful tool for the rapid and accurate production of small batches for personalized medicine as well as for clinical batches. A novel electronic liquid dispensing system (ELDS) was investigated to produce hard capsules with individualized dose [...] Read more.
An automated compounding device can be a useful tool for the rapid and accurate production of small batches for personalized medicine as well as for clinical batches. A novel electronic liquid dispensing system (ELDS) was investigated to produce hard capsules with individualized dose strengths. An ethanol-based solvent system containing the antihypertensive enalapril maleate was extruded through a cannula into prefilled capsules. The capsules were prefilled with a powder bed of mesoporous silica (Syloid 244 FP) or synthetic dibasic calcium phosphate anhydrous (Fujicalin). The dosing accuracy as well as content uniformity of ELDS was compared with manual preparation using a Hamilton syringe (HS). Both methods met the pharmacopeia criteria for all formulations with an acceptance value (AV) less than 15. Drug adherence to the capsule shells was also investigated. A recovery rate of 98% of enalapril maleate showed almost no drug loss, but the appropriateness of the new dispensing method. Full article
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