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Pharmaceutics
Special Issues
Nanoemulsions for Pharmaceutical and Biomedical Applications
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Nanoemulsions for Pharmaceutical and Biomedical Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: closed (30 April 2026) | Viewed by 1395

Special Issue Editor

Dr. Maciej Stawny

E-Mail Website
Guest Editor
Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, 60-780 Poznan, Poland
Interests: liver diseases; drug interactions; parenteral nutrition; hospital pharmacy; nanotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanoemulsions represent a promising class of colloidal carriers with broad potential in pharmaceutical and biomedical applications. Their nanoscale droplet size, high kinetic stability, and tunable interfacial properties enable the solubilization of poorly water-soluble compounds, protect sensitive bioactives from degradation, and provide opportunities for controlled and targeted delivery. Furthermore, their versatility across oral, parenteral, transdermal, ocular, nasal, and pulmonary routes underscores their relevance in translational medicine.

This Special Issue aims to showcase recent advances and future perspectives in the design, characterization, and application of nanoemulsions within pharmaceutical and biomedical research. We particularly welcome contributions that address innovative formulation strategies (high-energy and low-energy methods), mechanistic insights into stability and destabilization phenomena, surface functionalization for targeted delivery, and evaluation of biocompatibility, pharmacokinetics, biodistribution, and therapeutic outcomes in preclinical or clinical models. Studies focused on cutting-edge therapeutic applications such as oncology, vaccination, antimicrobial therapy, gene delivery, and theranostics are especially encouraged. Both original research articles and reviews are welcome.

This Special Issue will provide a comprehensive platform for disseminating advances in nanoemulsion science and technology, fostering cross-disciplinary dialogue, and accelerating the translation of these promising systems into clinical and industrial practice.

Dr. Maciej Stawny
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoemulsions
  • drug delivery systems
  • colloidal carriers
  • targeted therapy
  • translational medicine

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Published Papers (1 paper)

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Research

34 pages, 6483 KB  
Article
Myrrh Oil-Based Nanoemulsion Loaded with Curcumin and Insulin: Development, Characterization, and Evaluation of Enhanced Antibacterial and Diabetic Wound-Healing Activity
by Ayman Salama, Mona Qushawy, Nehal Elsherbiny, Helal F. Hetta, Saleh F. Alqifari, Mohamed A. Safwat, Wael M. Elsaed, Mahmoud Elsabahy, Yasmin N. Ramadan and Ghareb M. Soliman
Pharmaceutics 2026, 18(3), 369; https://doi.org/10.3390/pharmaceutics18030369 - 16 Mar 2026
Viewed by 1057
Abstract
Background/Objectives: Curcumin (CUR) has shown promising potential as a wound-healing agent for diabetic wounds; however, its efficacy is hindered by poor aqueous solubility and limited skin permeability. To overcome these limitations, CUR was loaded into myrrh oil-based nanoemulsions (NEs). Methods: The [...] Read more.
Background/Objectives: Curcumin (CUR) has shown promising potential as a wound-healing agent for diabetic wounds; however, its efficacy is hindered by poor aqueous solubility and limited skin permeability. To overcome these limitations, CUR was loaded into myrrh oil-based nanoemulsions (NEs). Methods: The NEs were optimized using a three-factor two-level D-optimal mixture design, and characterized for droplet size, polydispersity index, and zeta potential. The optimized NE was subjected to various stability testing and incorporated into a gel base containing insulin (INS) to form CUR-INS nanoemulgel (CUR-INS-NEG). The antibacterial efficacy of CUR-INS-NEG was tested against various bacterial strains, while its wound-healing effects were evaluated in a diabetic rat wound model. Results: The surfactant/co-surfactant concentration had a greater influence on the NE properties than the oil and aqueous phase concentrations. The optimal NE had a droplet size of 155.2 ± 0.8 nm, a polydispersity index of 0.28, and a zeta potential of −31.4 ± 0.8 mV. It demonstrated sustained drug release, with further release control upon incorporation into the gel base. CUR-INS-NEG demonstrated higher in vitro antibacterial efficacy compared with blank NEG, CUR gel, and INS gel. It also showed 2- and 4-fold reduction in the MIC against S. aureus and E. coli, respectively, compared with CUR gel. In a diabetic wound model, CUR-INS-NEG outperformed both CUR gel and INS gel by enhancing anti-inflammatory and antioxidant effects, as well as collagen deposition and endothelial cell proliferation. Conclusions: The CUR-INS-NEG emerges as an effective system for diabetic wound management, delivering complementary anti-inflammatory, antioxidant, and tissue-regenerative effects of myrrh oil, CUR, and INS. Full article
(This article belongs to the Special Issue Nanoemulsions for Pharmaceutical and Biomedical Applications)
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