Advances and Challenges in Nanomedicine: Translating Nanotechnology into Therapeutics for Cancer, Neurodegenerative, and Infectious Diseases

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 2587

Special Issue Editors


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Guest Editor
Department of Medicine, Surgery & Dentistry "Scuola Medica Salernitana", University of Salerno, Via S. Allende, 84081 Baronissi, Italy
Interests: nanomedicine; 3D culture; bioplotting; organ on chip; stem cells; tissue regeneration; regenerative medicine; cancer; histology and molecular biology analyses
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, Italy
Interests: drug delivery systems; nanomedicine; tissue engineering; microfluidics technology; lipid nanoparticles; liposomes; polyesters-based carriers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of nanomedicine holds immense promise for transforming therapeutic and diagnostic approaches, enabling targeted drug delivery, enhanced imaging, and personalized medicine solutions. Recent advances have led to a surge in the development of lipid nanoparticles, polymer-based carriers, and inorganic nanomaterials that are not only designed to improve drug stability and bioavailability but also to overcome traditional challenges associated with drug delivery, such as toxicity and biodistribution. This Special Issue seeks to showcase cutting-edge research and comprehensive reviews on the design, characterization, and clinical translation of nanomaterials in medicine. We invite manuscripts focusing on innovative formulations, nanoparticle-based gene therapies, immunotherapies, and theranostics, as well as on the regulatory and manufacturing challenges facing the field. We welcome submissions exploring nanomedicine's impact in emerging areas such as cancer, neurodegenerative diseases, and infectious diseases.

Topics of interest include, but are not limited to, the following:

  • Design and optimization of lipid nanoparticles, polymeric nanoparticles, and hybrid nanocarriers for targeted delivery;
  • Nanoformulations for gene therapy, including mRNA and siRNA delivery;
  • Advances in nanoparticle-mediated immunotherapy;
  • Overcoming physiological barriers with nano-based delivery systems;
  • Theranostic nanoparticles for simultaneous diagnosis and therapy;
  • Safety, toxicity, and immunogenicity of nanomedicines;
  • Regulatory and manufacturing perspectives on nanomedicine development;
  • Case studies of nanomedicine applications in cancer, infectious diseases, and neurological disorders.

We aim to bring together pioneering researchers and industry professionals to address the current advancements and challenges in translating nanotechnology into viable clinical solutions. This Special Issue will serve as a valuable resource for scientists and practitioners committed to advancing the frontier of nanomedicine.

Prof. Dr. Giovanna Della Porta
Dr. Erwin Pavel Lamparelli
Guest Editors

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Keywords

  • nanomedicine
  • targeted delivery
  • gene therapies
  • immunotherapies
  • cancer
  • infectious diseases
  • neurological disorders

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Published Papers (1 paper)

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Review

41 pages, 2093 KB  
Review
Cracking the Blood–Brain Barrier Code: Rational Nanomaterial Design for Next-Generation Neurological Therapies
by Lucio Nájera-Maldonado, Mariana Parra-González, Esperanza Peralta-Cuevas, Ashley J. Gutierrez-Onofre, Igor Garcia-Atutxa and Francisca Villanueva-Flores
Pharmaceutics 2025, 17(9), 1169; https://doi.org/10.3390/pharmaceutics17091169 - 6 Sep 2025
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Abstract
This review provides a mechanistic framework to strategically design nanoparticles capable of efficiently crossing the blood–brain barrier (BBB), a critical limitation in neurological treatments. We systematically analyze nanoparticle–BBB transport mechanisms, including receptor-mediated transcytosis, adsorptive-mediated transcytosis, and transient barrier modulation. Essential nanoparticle parameters (size, [...] Read more.
This review provides a mechanistic framework to strategically design nanoparticles capable of efficiently crossing the blood–brain barrier (BBB), a critical limitation in neurological treatments. We systematically analyze nanoparticle–BBB transport mechanisms, including receptor-mediated transcytosis, adsorptive-mediated transcytosis, and transient barrier modulation. Essential nanoparticle parameters (size, shape, stiffness, surface charge, and biofunctionalization) are evaluated for their role in enhancing brain targeting. For instance, receptor-targeted nanoparticles can significantly enhance brain uptake, achieving levels of up to 17.2% injected dose per gram (ID/g) in preclinical glioma models. Additionally, validated preclinical models (human-derived in vitro systems, rodents, and non-human primates) and advanced imaging techniques crucial for assessing nanoparticle performance are discussed. Distinct from prior BBB nanocarrier reviews that primarily catalogue mechanisms, this work (i) derives quantitative ‘design windows’ (size 10–100 nm, aspect ratio ~2–5, near-neutral ζ) linked to transcytosis efficiency, (ii) cross-walks human-relevant in vitro/in vivo models (including TEER thresholds and NHP evidence) into a translational decision guide, and (iii) integrates regulatory/toxicology readiness (ISO 10993-4, FDA/EMA, ICH) into practical checklists. We also curate recent (2020–2025) %ID/g brain-uptake data across lipidic, polymeric, protein, inorganic, and hybrid vectors to provide actionable, evidence-based rules for BBB design. Full article
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