Novel Approaches for Insulin Delivery
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 261
Editors
Interests: transplantation of solid organs and cells; islet transplantation; cell factories of biologics; insulin therapy; insulin SC absorption; continuous glucose monitors; canine, feline and equine diabetes; implantable subcutaneous devices.
Interests: islet purification and transplantation; pancreas transplantation; implantable devices for therapeutic cells; islet and beta cell evaluation; insulin delivery and pharmacokinetics; islet cell preservation, storage, and shipment.
Special Issue Information
Dear Colleagues,
In the century since animal insulin first became commercially available for the treatment of patients with Type 1 diabetes, innumerable investigators have sought to improve life-saving insulin treatment. Insulin itself has been genetically modified to tailor its pharmacokinetics to patient needs, and various excipients may be added to alter its absorption. In large part because of convenience, subcutaneous (SC) injection remains the predominant route of administration, but additional routes (oral, intradermal, intraperitoneal, vaginal, inhalatory, etc.) and novel delivery methods (pens, precision pumps, and microneedles) are often coupled with continuous glucose monitors by sophisticated algorithms, rendering them “smart”. Utilizing donated, isolated Islets of Langerhans as implants, either in the portal circulation or within encapsulating devices implanted SC, can provide the patient with a self-regulating insulin factory. Successes, particularly with portal islets, have encouraged scientists to pursue beta-cell-like stem cells as a potentially unlimited supply.
In this Special Issue, we seek to inform the scientific, medical, and public communities of recent advances fueling these applications and innovations, from computer modeling to novel pharmaceutics and cells to implantable micropumps directed by built-in glucose sensors and informed by AI. We encourage submissions of novel concepts ranging from hypotheses to clinically translated applications. All types of articles will be considered.
Prof. Dr. Charles W. Putnam
Prof. Dr. Klearchos K. Papas
Guest Editors
Manuscript Submission Information
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Keywords
- insulin
- insulin pharmacokinetics
- beta cells
- stem cells
- genetically modified
- devices
- routes of administration
- delivery
- novel
- cell therapy
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