Drugs in Dermatology: Topical Agent, Cosmeceuticals, Dermatological Drug Delivery, Natural Product in Dermatology, 2nd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: closed (31 May 2025) | Viewed by 1914

Special Issue Editor


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Guest Editor
Department of Applied Chemistry, Dongduk Women’s University, Seoul 136-714, Republic of Korea
Interests: bioavailability; flavonoid; β-cyclodextrin; inclusion complex; cyclosophoraoses
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Special Issue Information

Dear Colleagues,

Skin disease is influenced by both intrinsic (genetics) and extrinsic factors (environmental exposure). Pharmacologic agents are commonly prescribed for the treatment of many dermatological diseases. Many medicine remedies have been used based on scientific evidence and the results of randomized controlled trials. Nonetheless, there is a lack of standardization of bioactive ingredients in alterative and traditional medicine. Certain drug entities are used for different indications than those indicated by their FDA approval. Additionally, many dermatological drugs are also used in topical application to the site. Natural products such as polyphenols have been proven to be beneficial for reducing the risk of developing skin disease. Although various flavonoids exert useful biological activities, some have limited bioavailability due to low solubility and penetration. As a result, supramolecular complexation of carbohydrates or delivery systems with flavonoids has been suggested to increase solubility and thus improve bioavailability.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Pharmaceutical formulation of dermatological drugs;
  • Delivery and controlled-release systems for topical agents or cosmeceuticals;
  • Natural products in dermatology;
  • Drug targeting for dermal tissue;
  • Functional ingredients of cosmeceuticals: pharmacogenetics and pharmacogenomics;
  • Target discovery for skin aging or hair regrowth.

We look forward to receiving your contributions.

Prof. Dr. Seyeon Park
Guest Editor

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Keywords

  • skin disease
  • dermatological drugs
  • topical agent
  • cosmeceuticals
  • natural products
  • drug targeting
  • functional ingredients
  • skin aging
  • hair regrowth

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Published Papers (1 paper)

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Review

12 pages, 213 KiB  
Review
Exosomes in Dermatology: Emerging Roles in Skin Health and Disease
by Salman Bin Dayel and Ramadan S. Hussein
Pharmaceutics 2025, 17(5), 600; https://doi.org/10.3390/pharmaceutics17050600 - 2 May 2025
Viewed by 1649
Abstract
Background/Objectives: Exosomes, nanosized vesicles secreted by diverse cell types, have emerged as critical mediators of intercellular communication, tissue repair, and disease pathogenesis. Their roles in dermatology are increasingly recognized, influencing skin health and the progression of various dermatological conditions. This review aims to [...] Read more.
Background/Objectives: Exosomes, nanosized vesicles secreted by diverse cell types, have emerged as critical mediators of intercellular communication, tissue repair, and disease pathogenesis. Their roles in dermatology are increasingly recognized, influencing skin health and the progression of various dermatological conditions. This review aims to explore the biogenesis, composition, and mechanisms of exosome uptake in skin cells and their implications in dermatological research and clinical practice. Methods: A comprehensive review of the existing literature was conducted to elucidate the biological composition of exosomes, their roles in skin homeostasis, and their involvement in processes, such as wound healing, tissue regeneration, and barrier function maintenance. This review also examined the diagnostic and therapeutic potential of exosomes in conditions such as psoriasis, eczema, acne, and skin cancer. Results: Exosomes were found to contain intricate compositions, including proteins, lipids, nucleic acids, and bioactive molecules, crucial for maintaining skin homeostasis. They demonstrated significant roles in modulating wound healing and skin regeneration. Emerging evidence highlights their involvement in dermatological conditions and their potential as diagnostic biomarkers and therapeutic agents. Exosome-based approaches hold promise for advancing disease management, although challenges remain in translating these findings into clinical applications. Conclusions: Exosomes represent a promising frontier in dermatology, with the potential to revolutionize the understanding, diagnosis, and treatment of skin-related disorders. Despite the challenges, their complexity and versatility underscore their potential in developing personalized skin health strategies. Further research is warranted to address the existing gaps and harness the full therapeutic potential of exosomes in dermatological applications. Full article
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