Biomimetic Drug Delivery Systems for Disease Treatment

Dear Colleagues,

Biomimetic drug delivery systems have emerged as promising strategies to overcome the multiple physiological and pathological barriers that limit the therapeutic efficacy of conventional treatments. By mimicking the structural, functional, or behavioral features of natural biological entities, such as cells, membranes, and extracellular vesicles, these systems enable enhanced stability, prolonged circulation, and improved site-specific accumulation of therapeutic agents. Beyond increasing bioavailability and protecting cargos from premature degradation, biomimetic carriers facilitate tissue penetration and cellular internalization, which are critical for effective treatment of complex diseases. The rational design of strategies to regulate the transport of therapeutics across biological barriers, including vascular, epithelial, and cellular membranes, has thus become an imperative challenge for improving therapeutic outcomes.

This Special Issue will provide readers with an overview of current advances in biomimetic drug delivery systems for disease treatment, highlighting innovative design strategies, functional mechanisms, and emerging translational applications. Particular emphasis will be placed on systems that enable precise targeting, controlled release, and enhanced interaction with the disease microenvironment. We welcome original research articles and comprehensive reviews covering the fabrication, structure–function relationships, therapeutic performance, and clinical translation potential of biomimetic delivery platforms.

Prof. Dr. Lin Mei
Dr. Ting Chen
Guest Editors

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