New Strategies to Improve Oral Drug Delivery for Disease Treatment

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 1863

Special Issue Editors

1. State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
2. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China
Interests: biomaterials; drug delivery; cancer immunotherapy; nanomedicine; cancer nanotechnology; molecular pharmaceutics
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Guest Editor
Department of Pharmacy, West China School of Medicine, Sichuan University, Chengdu 610041, China
Interests: drug delivery; nanomedicine; oral delivery; gastrointestinal diseases; metabolic diseases; gut hormones

Special Issue Information

Dear Colleagues,

Oral administration provides a non-invasive and convenient approach for drug delivery. However, a wide range of drugs (e.g., peptides, proteins, anticancer drugs and vaccines) must be parenterally injected due to their poor oral bioavailability within the harsh gastrointestinal environment (such as low pH and various digestive enzymes), due to the presence of mucosal barries, epithelial barriers and spatiotemporal variance in physiological parameters. By overcoming the biological, chemical and physiological barriers of the gastrointestinal tract, strategies such as the use of nanoparticles, chemical enhancers, prodrugs and oral devices could represent leading and innovative approaches for treating many diseases via the oral route, especially gastrointestinal diseases and chronic diseases.

This Special Issue aims to report on research and breakthroughs in the field of oral drug delivery. We invite research articles and review articles that focus on interesting approaches to oral drug delivery and improved treatment strategies for various diseases.

Prof. Dr. Lin Mei
Prof. Dr. Yining Xu
Guest Editors

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Keywords

  • oral delivery
  • gastrointestinal diseases
  • chronic diseases
  • gastrointestinal tract
  • biologic agents

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Published Papers (1 paper)

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Review

33 pages, 2566 KiB  
Review
Advances in Oral Biomacromolecule Therapies for Metabolic Diseases
by Qiuxia Jiao, Yuan Huang, Jinhan He and Yining Xu
Pharmaceutics 2025, 17(2), 238; https://doi.org/10.3390/pharmaceutics17020238 - 12 Feb 2025
Viewed by 1196
Abstract
Metabolic diseases like obesity and diabetes are on the rise, and therapies with biomacromolecules (such as proteins, peptides, antibodies, and oligonucleotides) play a crucial role in their treatment. However, these drugs are traditionally injected. For patients with chronic diseases (e.g., metabolic diseases), long-term [...] Read more.
Metabolic diseases like obesity and diabetes are on the rise, and therapies with biomacromolecules (such as proteins, peptides, antibodies, and oligonucleotides) play a crucial role in their treatment. However, these drugs are traditionally injected. For patients with chronic diseases (e.g., metabolic diseases), long-term injections are accompanied by inconvenience and low compliance. Oral administration is preferred, but the delivery of biomacromolecules is challenging due to gastrointestinal barriers. In this article, we introduce the available biomacromolecule drugs for the treatment of metabolic diseases. The gastrointestinal barriers to oral drug delivery and strategies to overcome these barriers are also explored. We then discuss strategies for alleviating metabolic defects, including glucose metabolism, lipid metabolism, and energy metabolism, with oral biomacromolecules such as insulin, glucagon-like peptide-1 receptor agonists, proprotein convertase subtilisin/kexin type 9 inhibitors, fibroblast growth factor 21 analogues, and peptide YY analogues. Full article
(This article belongs to the Special Issue New Strategies to Improve Oral Drug Delivery for Disease Treatment)
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