Smart Nanomaterials for Diagnosis and Therapy of Diseases

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (15 July 2022) | Viewed by 2849

Special Issue Editors

Politecnico di Torino, Department of Applied Science and Technology, Corso Duca degli Abruzzi 24, 10129 Torino, Italy
Interests: nanomedicine; nanotechnology; extracellular vesicles; zinc oxide; acoustic cavitation; ultrasound-assisted therapies; drug delivery
Special Issues, Collections and Topics in MDPI journals
Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy
Interests: cancer therapy; cancer biology; nanomaterials; ultrasound; sonodynamic therapy; zinc oxide; reactive oxygen species

Special Issue Information

Dear Colleagues,

The use of nanomedicines, i.e., nanotechnology applied to medicine for diagnosis and treatment of different diseases, has attracted great interest in recent years, and not solely for cancer therapy.

Several nanosized materials have been widely investigated for this purpose, exploiting their intrinsic unique properties, although the exact mechanism of action is often subject to debate. Additionally, their activity has been optimized through the addition of different coatings, e.g., to improve chemical stability and stealth properties, or even the presence of targeting agents, which reduce off-targets while achieving powerful “smart” nanoplatforms for the early detection, treatment and possibly resolution of diseases.

This Special Issue aims to collect research or review articles that focus on the investigation of nanomaterials, e.g., nanoparticles, with particular emphasis on exploring the study of innovative solutions to enhance nanoparticle properties and develop new effective diagnostic, therapeutic or theranostic approaches with clear comprehension of the nanoparticle functioning mechanisms.

Prof. Dr. Valentina Cauda
Dr. Luisa Racca
Guest Editors

Manuscript Submission Information

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Keywords

  • nanomaterials
  • nanoparticles
  • coatings
  • targeting
  • diagnosis
  • therapy of diseases
  • drug delivery
  • theranostic
  • cancer therapy
  • infectious diseases.

Published Papers (1 paper)

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Research

15 pages, 2617 KiB  
Article
Silver Nanofunctionalized Stent after Radiofrequency Ablation Suppresses Tissue Hyperplasia and Bacterial Growth
by Yubeen Park, Dong-Sung Won, Ga-Hyun Bae, Dae Sung Ryu, Jeon Min Kang, Ji Won Kim, Song Hee Kim, Chu Hui Zeng, Wooram Park, Sang Soo Lee and Jung-Hoon Park
Pharmaceutics 2022, 14(2), 412; https://doi.org/10.3390/pharmaceutics14020412 - 14 Feb 2022
Cited by 5 | Viewed by 2330
Abstract
Intraductal radiofrequency (RF) ablation combined with placement of a self-expandable metal stent (SEMS) for malignant biliary obstruction has risks such as stent- and heat-induced biliary sludge and restenosis. Here, we investigated the efficacy of a silver nanoparticles (AgNPs)-coated SEMS to inhibit tissue hyperplasia [...] Read more.
Intraductal radiofrequency (RF) ablation combined with placement of a self-expandable metal stent (SEMS) for malignant biliary obstruction has risks such as stent- and heat-induced biliary sludge and restenosis. Here, we investigated the efficacy of a silver nanoparticles (AgNPs)-coated SEMS to inhibit tissue hyperplasia and bacterial growth caused by RF ablation with stent placement in the rabbit bile duct. The release behavior and antibacterial effects of AgNPs-coated SEMSs were evaluated. Then, SEMSs were successfully placed in all rabbits immediately after RF ablation. Ag ions were rapidly released at the beginning and then showed a gradual release behavior. The AgNPs-coated SEMS significantly inhibited bacterial activity compared to the uncoated SEMS (p < 0.05). Cholangiography and histological examination confirmed that the level of tissue hyperplasia was significantly lower in the AgNPs group than in the control group (all p < 0.05). Immunohistochemistry analyses revealed that TUNEL-, HSP 70-, and α-SMA-positive areas were significantly lower in the AgNPs group than in the control group (all p < 0.05). Intraductal RF ablation combined with nanofunctionalized stent placement represents a promising new approach for suppressing thermal damage as well as stent-induced tissue hyperplasia and bacterial growth. Full article
(This article belongs to the Special Issue Smart Nanomaterials for Diagnosis and Therapy of Diseases)
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