Compounds and Drug Delivery for Diabetes Treatment

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (30 September 2025) | Viewed by 1092

Special Issue Editors


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Guest Editor
Division of Pharmacology, Faculty of Pharmacy, Rhodes University, Makhanda 6139, South Africa
Interests: diabetes; drug discovery; drug delivery

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Guest Editor
Human Physiology, University of KwaZulu Natal, Durban 4000, South Africa
Interests: prediabetes; diabetes; diabetes management

Special Issue Information

Dear Colleagues,

Innovations in drug discovery and delivery have revolutionized the management of diabetes mellitus. Reports suggests that diabetes prevalence remains high on a global scale and is projected to increase in the future. Therefore, we must continue to search for potential pharmacological agents that complement existing pharmacotherapeutic options. Furthermore, adequate glycaemic control and adverse drug effects are directly linked to the pharmacokinetic and pharmacodynamic profiles of drugs, highlighting the necessity to explore drug delivery systems that can improve diabetes management. Technological advancements in drug delivery could enable us to overcome some of the challenges associated with diabetes management, therefore improving pharmacotherapeutic outcomes.

This Special Issue aims to showcase cutting-edge research on drug discovery and delivery strategies for diabetes mellitus. Accordingly, we welcome contributions on the discovery and development of drugs (containing synthetic and natural compounds) that target diabetes mellitus and their associated complications. Furthermore, we seek contributions on innovative drug delivery research and strategies to improve the management of diabetes.

Dr. Ntethelelo Sibiya
Dr. Andile Khathi
Guest Editors

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Keywords

  • diabetes
  • antidiabetic compounds
  • delivery systems
  • glycaemic control
  • insulin

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Published Papers (1 paper)

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Review

25 pages, 3792 KB  
Review
Emerging Insulin Analogues: A Glimpse into How Insulin Analogues May Look in the near Future
by Ntethelelo Sibiya, Lorah Dzimwasha, Samarah Zvandasara, Amanda Zuma and Andile Khathi
Pharmaceutics 2025, 17(10), 1239; https://doi.org/10.3390/pharmaceutics17101239 - 23 Sep 2025
Viewed by 727
Abstract
The use of insulin as a treatment for diabetes mellitus has been marred by several challenges. These setbacks incurred in an attempt to better manage diabetes, together with past innovative strategies, have encouraged science and the clinical community to continue to endeavour for [...] Read more.
The use of insulin as a treatment for diabetes mellitus has been marred by several challenges. These setbacks incurred in an attempt to better manage diabetes, together with past innovative strategies, have encouraged science and the clinical community to continue to endeavour for an ideal insulin analogue that demonstrates heightened pharmacokinetic profiles and thermal stability. This review therefore seeks to provide an update on emerging insulin analogues. This review aims to update the science and clinical community of the recent developments on novel insulin analogues design and engineering. Through this exercise, we believe this review consolidates cutting-edge innovations on insulin development and diabetes management. The accelerated innovation of design and engineering in the biotechnology and peptide field has seen more insulin analogues reported in the last decade. Although the analogues are often limited to preclinical studies, Degludec, Icodec, and Efsitora have been the exceptions. The emerging insulin analogues include those with extended pharmacokinetic profile, increased thermostability, are glucose-responsive, and are hepato-preferential insulin analogues. Due to the fast pace of innovation in the design of insulin analogues, more insulin analogues are likely to emerge in the clinical space in the near future. Such innovations should be applauded and encouraged as they aim to strive for better management of diabetes mellitus. Full article
(This article belongs to the Special Issue Compounds and Drug Delivery for Diabetes Treatment)
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