Overcoming Biological Barriers: Novel Strategies in Drug Delivery
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 57
Special Issue Editors
Interests: blood-brain barrier; bioequivalence; in vivo predictive dissolution; in vitro-in vivo correlation; PBPK; pharmacokinetics
Special Issues, Collections and Topics in MDPI journals
Interests: PBPK; biowaivers; pharmacokinetics; dissolution; absorption; drug solubility
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Effective drug delivery remains one of the greatest challenges in modern medicine due to the presence of complex biological barriers that protect the body but also hinder therapeutic access to target tissues. These barriers include the intestinal epithelium, the blood–brain barrier (BBB), mucosal membranes, the skin, the blood–testis and placental barriers, as well as specialized stromal and hydrogels within tissues.
Each barrier presents unique structural and functional challenges. To overcome these obstacles, innovative drug delivery strategies have been developed, such as nanotechnology-based carriers that enhance tissue penetration; biomaterial engineering approaches that dynamically interact with biological barriers; cell-penetrating peptides (CPPs) to facilitate cellular uptake; hydrogel-based systems for controlled release; and receptor-mediated and targeted delivery mechanisms that exploit endogenous transport pathways.
This Special Issue will showcase cutting-edge research and reviews on the mechanisms by which biological barriers impede drug delivery and the latest technological advances designed to overcome them. Contributions will span fundamental studies on barrier biology, novel carrier design, translational approaches, and clinical perspectives, with a focus on improving therapeutic outcomes for diseases that have so far been limited by these formidable physiological defences.
Researchers are invited to contribute original articles and reviews that highlight innovative solutions and future directions in the field of drug delivery across biological barriers.
Dr. Bárbara Sánchez-Dengra
Prof. Dr. Isabel González-Álvarez
Guest Editors
Manuscript Submission Information
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Keywords
- biological barriers
- drug delivery systems
- permeability
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