Next Generation Platform for the Production of Biopharmaceuticals
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 2905
Special Issue Editor
Special Issue Information
Dear Colleagues,
The demand for biopharmaceuticals, such as therapeutic proteins, is increasing, and healthcare systems are facing tremendous costs to address unmet medical needs. Therefore, to meet the growing demand for biopharmaceuticals, the development of highly efficient production platforms is warranted. Although state-of-the-art industrial manufacturing processes allow productivity of over g/L for numerous monoclonal antibodies, the expansion of the biopharmaceutical industry pipeline with a wide range of non-native proteins, such as bispecific antibodies and fusion proteins, poses questions regarding both the manufacturability and timelines to achieve a commercially viable solution. This Special Issue aims to explore the emerging trends in the platforms and manufacturing processes for the production of biopharmaceuticals. In this Special Issue, original research articles and reviews are welcome. Research areas may include but not be limited to recent advances in mammalian-based production of biopharmaceuticals and manufacturing platforms, alternative mammalian expression platforms, including cell-free and gene-based expression systems, issues in manufacturing therapeutics in a non-native format, etc.
Dr. Jae Seong Lee
Guest Editor
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Keywords
- biopharmaceutical production using mammalian cells
- mammalian cell culture engineering
- alternative mammalian expression/manufacturing platform
- cell-free expression system for therapeutic protein production
- gene-based (DNA, RNA) biopharmaceutical production
- non-native difficult-to-express therapeutic protein
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