Pharmaceutical and Biomedical Applications of Cyclodextrins and Derivatives
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".
Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 27153
Special Issue Editors
Interests: cyclodextrins; host-guest complexation; drug delivery; biological barriers; cellular effects of cyclodextrins; pharmacokinetics and tissue distribution of cyclodextrins
Special Issue Information
Dear Colleagues,
Cyclodextrin research has had almost continuous progress for more than a hundred years, and in recent decades new ideas concerning pharmaceutical and biomedical applications have spread. The widely known pharmaceutical application of cyclodextrins is based on their efficient complexing ability to improve the solubility and bioavailability of poorly soluble small drug molecules. Indeed, to this day, complexation is one of the most important uses of cyclodextrins. On the other hand, recently, cyclodextrins have also been used for the formulation of large molecules, such as peptides and nucleic acids. Applying cyclodextrin derivatives including polymers, new cyclodextrin-based systems were developed for improved drug delivery. Despite the extensive research, complexation, and formulation with cyclodextrins has untapped potential.
Host–guest interaction is also the basis of their effects in biological systems, as they can interact with biomolecules. From this point of view, they are not inactive molecules and this ability can be used in biomedical applications. Great progress can be seen in the research of infectious diseases, cardiovascular diseases, and cholesterol-related neurodegenerative diseases. A milestone of the history of cyclodextrins is the approval of 2-hydroxypropyl-β-cyclodextrin as an orphan drug in the treatment of Niemann–Pick disease type C. Nevertheless, there are still many unresolved questions in the field of biological activities and the behavior of cyclodextrins at different levels of biological systems. Effects on cellular organelles, cells, barriers, tissues, and organs must be studied to reveal and understand their full spectrum of actions.
This Special Issue will collect the latest innovative researches in the field of pharmaceutical and biomedical applications of cyclodextrins. The highlighted topics are closely related to each other and to understand the effects of cyclodextrins and reveal their potentials these questions must be examined in a complex manner. Reviews, original research articles, and short communications will be considered.
Dr. Ferenc Fenyvesi
Dr. Judit Váradi
Guest Editor
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Keywords
- Complexation with cyclodextrins
- Host–guest interaction
- Drug delivery
- Biological effects of cyclodextrins
- Cyclodextrin-based therapeutics
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