Nanoadjuvants for Drug Delivery and Immunotherapy
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 21
Special Issue Editors
Interests: nano-aluminum adjuvant for cancer immunotherapy; inflammation treatment; and neurodegenerative disease therapy
Special Issue Information
Dear Colleagues,
Traditional adjuvants like aluminum salts and emulsions have been foundational in vaccinology. However, their conventional macro-formulations face several limitations, including poor targeting efficiency, inconsistent immunomodulatory effects, and potential systemic toxicity. Nanoadjuvants—encompassing lipid nanoparticles (LNPs), polymeric systems, and inorganic carriers (nano-aluminum)—are engineered to overcome these hurdles. These properties include enhanced bioavailability, precise tissue- and cell-specific targeting, and tunable immunostimulation, thereby revolutionizing both drug delivery (e.g., for biologics, small-molecule therapeutics) and immunotherapy (e.g., cancer, infectious diseases, autoimmune disorder management). Despite notable advancements, critical challenges remain in optimizing nanoadjuvants formulation stability, clarifying the mechanisms underlying immunomodulation, scaling up production for clinical translation, and establishing long-term safety profiles.
This Special Issue of Pharmaceutics aims to compile high-quality original research, reviews, and perspective articles that advance nanoadjuvants science. Key focuses include novel organic and inorganic nanoadjuvant synthesis and functionalization strategies, in-depth mechanistic studies on immunomodulation, in vitro and in vivo efficacy evaluations, and translational studies that bridge preclinical and clinical development. By integrating insights from academia and industry across pharmaceutics, materials science, and immunology, this issue will serve as a definitive resource for researchers. The ultimate goal is to accelerate the translation of safe and effective nanoadjuvant technologies into next-generation therapies for cancer, infectious diseases, and beyond.
Dr. Lingxiao Zhang
Guest Editor
Dr. Maoze Wang
Guest Editor Assistant
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Keywords
- adjuvants
- nanoadjuvants
- nano-aluminum adjuvants
- nanoparticles
- vaccines
- immunotherapy
- drug delivery system
- clinical translation
- biosafety
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