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Pharmaceutics
Special Issues
New Nanomedicine Technologies: Drug Formulation and Drug Delivery System Aspects
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New Nanomedicine Technologies: Drug Formulation and Drug Delivery System Aspects

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 1301

Special Issue Editors

Dr. Sonia Pinho

E-Mail Website
Guest Editor
Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
Interests: nanomaterials; nanoparticles; functionalization; drug delivery; theranostics; bioimaging; nanotechnology; nanoparticle; nanomedicine
Special Issues, Collections and Topics in MDPI journals
Dr. Aji Alex Moothedathu Raynold

E-Mail Website
Guest Editor
Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
Interests: nanotechnology; nanoparticle; nanomedicine; drug delivery; gene delivery; nanocarrier

Special Issue Information

Dear Colleagues,

We are delighted to invite you to contribute to a Special Issue of our esteemed journal, entitled "New Nanomedicine Technologies: Drug Formulation and Drug Delivery System Aspects". This Issue aims to explore and showcase original, high-quality publications covering current and novel research activities within the fields of nano-bioengineering, nanomedicine, nano-pharmaceuticals, and pharmaceutical science.

Advancements in nanotechnology have revolutionized the field of medicine, particularly in drug formulation and delivery systems. This Special Issue serves as a platform to present cutting-edge research that addresses challenges and explores innovative solutions in nanomedicine technologies. We encourage submissions that delve into novel approaches for drug formulation, advanced nanocarrier systems, targeted drug delivery methods, bioimaging techniques, and personalized medicine applications. By fostering the exchange of knowledge and ideas, this Special Issue will contribute to the development of safer, more efficient, and patient-centric drug delivery systems.

Dr. Sonia Pinho
Dr. Aji Alex Moothedathu Raynold
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomedicine
  • drug formulation
  • drug delivery systems
  • nanocarriers
  • targeted drug delivery
  • bioimaging
  • personalized medicine
  • nanotechnology
  • pharmaceutical science
  • nano-bioengineering

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

16 pages, 5477 KiB  
Article
Development and Optimization of Nano-Hydroxyapatite Encapsulating Tocotrienol-Rich Fraction Formulation Using Response Surface Methodology
by Anis Syauqina Mohd Zaffarin, Shiow-Fern Ng, Min Hwei Ng, Haniza Hassan and Ekram Alias
Pharmaceutics 2025, 17(1), 10; https://doi.org/10.3390/pharmaceutics17010010 - 24 Dec 2024
Viewed by 826
Abstract
Background/Objective: The tocotrienol-rich fraction (TRF) is a lipid-soluble vitamin that has good antioxidant and anti-inflammatory properties. The TRF is widely studied as a potential treatment for various diseases, including bone diseases. However, its application is limited due to its poor oral bioavailability [...] Read more.
Background/Objective: The tocotrienol-rich fraction (TRF) is a lipid-soluble vitamin that has good antioxidant and anti-inflammatory properties. The TRF is widely studied as a potential treatment for various diseases, including bone diseases. However, its application is limited due to its poor oral bioavailability profile, warranting an innovative approach to overcome its pharmacokinetic limitations. Recently, the nano-hydroxyapatite (nHA) has been investigated as a drug delivery vehicle for various drugs and active compounds owing to its excellent biocompatibility, biodegradability, and osteogenic properties. The nHA is also a well-known biomaterial which has chemical and structural similarities to bone minerals. Hence, we aim to explore the use of the nHA as a potential nanocarrier for the TRF. Methods: In this study, we develop and optimize the formulation of an nHA-encapsulating TRF (nHA/TRF) by employing the response surface methodology (RSM). Results: RSM outcomes reveal that the mass of the nHA, the concentration of the TRF, and the incubation time have a significant effect on the particle size, zeta potential, and encapsulation efficiency of the nHA/TRF. The outcomes for the optimized formulation are not significantly different from the predicted RSM outcomes. The optimized nHA/TRF formulation is freeze-dried and results in an average particle size of ~270 nm, a negative zeta potential value of ~−20 mV, a polydispersity index of <0.4, and an encapsulation efficiency of ~18.1%. Transmission electron microscopy (TEM) shows that the freeze-dried nHA/TRF has a spherical structure. Conclusions: Taken together, the above findings indicate that the nHA may be established as a nanocarrier for efficient delivery of the TRF, as demonstrated by the promising physical properties. Full article
(This article belongs to the Special Issue New Nanomedicine Technologies: Drug Formulation and Drug Delivery System Aspects)
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