Multifunctional Nanomaterials in Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 483

Special Issue Editor

NextGen Healthcare Materials Lab, School of Life Science, Handong Global University, Pohang 37554, Republic of Korea
Interests: drug delivery; crossing the blood-brain barrier; neurodegenerative diseases; carbon quantum dots; polymer; polymer nanoparticles; upconversion nanoparticles; counterion condensation of polyelectrolytes; gold/silver nanoparticles; bioimaging/advanced fluorescence microscopy; surface-enhanced Raman scattering (SERS)
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Special Issue Information

Dear Colleagues,

The Special Issue titled “Multifunctional Nanomaterials in Drug Delivery” aims to explore the latest advancements in nanotechnology and its pivotal role in revolutionizing drug delivery systems. With their unique physical, chemical, and biological properties, multifunctional nanomaterials have become an integral part of modern therapeutics. These nanomaterials enable the design of innovative delivery platforms with enhanced precision, efficiency, and patient compliance.

This Special Issue welcomes cutting-edge research and comprehensive reviews that present the development, characterization, and application of multifunctional nanomaterials for drug delivery. The focus is on exploring novel strategies to improve bioavailability, targeting efficiency, and controlled release of therapeutic agents while addressing challenges related to toxicity, scalability, and clinical translation.

We invite submissions that cover, but are not limited to, the following topics:

- Design and synthesis of novel nanocarriers for drug delivery;

- Multifunctional nanomaterials for targeted and stimuli-responsive drug release;

- Nanomaterials for crossing biological barriers, including the blood–brain barrier;

- Applications of nanotechnology in gene delivery and immunotherapy;

- Biocompatibility and biodegradability of nanomaterials in clinical applications;

- Advances in imaging-guided drug delivery using nanomaterials;

- Addressing challenges in scaling up and clinical translation of nanomaterial-based delivery systems;

- Emerging trends in hybrid nanomaterials for combined therapeutic and diagnostic applications.

Researchers are encouraged to submit original research articles and comprehensive reviews that align with the scope of this Special Issue. All manuscripts will undergo rigorous peer review to ensure high-quality contributions to the field.

Dr. Ranjit De
Guest Editor

Manuscript Submission Information

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Keywords

  • nanomaterials
  • bioavailability
  • targeting efficiency
  • controlled release
  • drug delivery

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Published Papers (1 paper)

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Research

15 pages, 3660 KiB  
Article
Microencapsulation of Analgesics as an Analog Form of Medicine
by Aidana Nakipekova, Bates Kudaibergenova, Arkady S. Abdurashitov and Gleb B. Sukhorukov
Pharmaceutics 2025, 17(7), 916; https://doi.org/10.3390/pharmaceutics17070916 - 15 Jul 2025
Viewed by 262
Abstract
Objectives: This research focuses on the development of fabrication approaches for microparticles intended for controlled drug delivery. The primary objective is to identify the most suitable polymer type, particle size, and morphology for encapsulating a water-soluble crystalline drug. Optimizing these parameters may enhance [...] Read more.
Objectives: This research focuses on the development of fabrication approaches for microparticles intended for controlled drug delivery. The primary objective is to identify the most suitable polymer type, particle size, and morphology for encapsulating a water-soluble crystalline drug. Optimizing these parameters may enhance structural stability and prolong the release of this active substance. Methods: The microparticles were fabricated through the encapsulation of a drug substance within a polymer carrier and employing polymer casting on prepatterned surfaces, followed by the loading of drug precipitates and the application of a sealing layer. The crystalline powder 1-allyl-2,5-dimethylpiperidol-4 hydrochloride served as the core cargo material, while the walls of these particles were composed of polylactic acid (PLA) and a poly (α-caprolactone) (PCL) in a 70:30 composition ratio. Results: The size and volume of the microparticles were found to be dependent on the geometric parameters of the template and the concentration of the polymer solutions. The study demonstrates the formation, physical dimensions, and particle count at varied polymer compositions and concentrations. The formation of the PLA and PCL mixture occurred solely through physical interactions. Scanning electron microscopy (SEM) and optical microscopy were employed to observe the appearance and physical dimensions of the microparticles. The obtained data confirm that tailored polymer compositions can yield consistent particle morphology and a suitable drug elution rate. Conclusions: The results indicate that microparticles sealed with an optimal polymer composition exhibit enhanced release properties. This finding highlights the feasibility of microencapsulation at precise ratios and concentrations of polymers to achieve the long-lasting effects of water-soluble drugs. Full article
(This article belongs to the Special Issue Multifunctional Nanomaterials in Drug Delivery)
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