Surfactants and Amphiphiles as Key Components in Diverse Pharmaceutical and Biomedical Applications
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 132
Special Issue Editors
Interests: drug; solubility; surfactants
Interests: surfactants; self-assembling; liposomes; nanoparticles; calorimetric techniques; ultrasound spectroscopy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The rational design of surfactants and amphiphiles has become a powerful strategy for addressing key challenges in biomedical and pharmaceutical sciences. By precisely tuning molecular architecture, such as head-group chemistry, hydrophobic domains, linker structure, modern amphiphiles can be engineered to exhibit programmable self-assembly, controlled biological interactions, and enhanced therapeutic performance. These design principles enable amphiphiles to move beyond passive formulation roles towards active functions in drug delivery, diagnostics, and disease modulation.
This Special Issue focuses on the rational design, synthesis, and structure–function relationships of novel amphiphilic systems for pharmaceutical formulation and drug delivery applications. Emphasis is placed on the development of advanced amphiphilic architectures incorporating varied chemical constituents and responsive functionalities that enable tailored bioavailability and targeted drug delivery performance. Contributions that elucidate how molecular design principles govern self-assembly behavior, pharmacokinetics, biocompatibility, and therapeutic performance are particularly encouraged. Experimental, theoretical, and computational studies, as well as translational perspectives, are welcome. By integrating molecular design with pharmaceutical functionality, this Special Issue aims to demonstrate how next-generation amphiphiles are redefining the field by serving as key functional components in advanced biomedical and pharmaceutical technologies.
Dr. Abhishek Kumar Singh
Dr. Diego Romano Perinelli
Guest Editors
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Keywords
- amphiphile design
- structure–function relationships
- self-assembly
- nanomedicine
- drug delivery
- supramolecular chemistry
- pharmaceutical applications
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