Spray Drying and Encapsulation of Pharmaceuticals and Phytopharmaceuticals

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 612

Special Issue Editors


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Guest Editor
Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café s/n, Ribeirão Preto 14040-903, SP, Brazil
Interests: spray drying and encapsulation of pharmaceuticals and phytopharmaceuticals; nanotechnology; enzyme immobilization; granulation and particle coating; process optimization
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Guest Editor
Colombian Corporation for Agricultural Research - AGROSAVIA, Bioproducts Department, Bogota, Colombia
Interests: spray drying and encapsulation of pharmaceuticals and phytopharmaceuticals; process optimization; bioproducts

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Guest Editor
Center for Natural and Human Sciences (CCNH), Federal University of ABC, Santo André 14040-903, SP, Brazil
Interests: spray drying of bioproducts; enzyme technology; biopharmaceutics; process optimization

Special Issue Information

Dear Colleagues,

The spray drying and encapsulation of pharmaceuticals and phytopharmaceuticals are widely used in the pharmaceutical sector for the powder production and manufacture of innovative delivery systems. Important applications of spray drying in pharmaceutical and herbal technology include the production of powders with high flowability and with direct compression capability; the development of innovative drug delivery systems, nano- and microcapsules loaded with active pharmaceutical and phytopharmaceutical ingredients (e.g., essential oils, phytochemicals and plant extracts); the production of inhalable powders for pulmonary drug delivery; the manufacture of redispersible powders, proliposomes, and molecular inclusion complexes; enhancement of the bioavailability and solubility of poorly soluble pharmaceuticals and phytochemicals; and the drying of thermosensitive pharmaceuticals and biopharmaceuticals.

Spray drying exhibits several advantages over other drying techniques, such as the capability of continuous production, applications for small- and large-scale production, and of modulation of the physicochemical product properties (e.g., moisture content, water activity, wettability, solubility, redispersion capacity, powder size, density). Usually, fine powders are produced, which may require further post-processing. Spray cooling or spray congealing is a process with certain similarity to spray drying, but in this specific case the feed is atomized in the melted state and a low-temperature gas is introduced to the system, promoting the particles’ solidification.

Therefore, we invite research groups working with the basic and applied themes related to the "Spray Drying of Pharmaceuticals and Phytopharmaceuticals" to contribute to this Special Issue of Pharmaceutics. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the production of direct compression powders, drying of thermosensitive products, encapsulation of drugs and herbal products, production of inhalable powders, improvement of bioavailability and solubility, and enhancement of product shelf-life.

In advance, we thank the authors who take time in their busy schedules to contribute to this Special Issue of Pharmaceutics.

We look forward to receiving your contributions.

Prof. Dr. Wanderley Pereira Oliveira
Dr. Diego Francisco Cortés-Rojas
Prof. Dr. Tales Alexandre Costa-Silva
Guest Editors

Manuscript Submission Information

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Keywords

  • spray drying
  • spray congealing
  • encapsulation
  • delivery systems
  • proliposomes
  • molecular inclusion complexes
  • drug delivery system
  • bioavailability
  • inhalable powders
  • pharmaceuticals
  • phytopharmaceuticals
  • biopharmaceutical
  • micro- and nanoencapsulation
  • pharmaceutical technology
  • herbal technology

Published Papers (1 paper)

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Research

19 pages, 5058 KiB  
Article
Development and Efficacy Evaluation of Innovative Cosmetic Formulations with Caryocar brasiliense Fruit Pulp Oil Encapsulated in Freeze-Dried Liposomes
by Letícia Kakuda, Patrícia M. B. G. Maia Campos and Wanderley P. Oliveira
Pharmaceutics 2024, 16(5), 595; https://doi.org/10.3390/pharmaceutics16050595 (registering DOI) - 27 Apr 2024
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Abstract
Encapsulation and drying technologies allow the engineering of innovative raw materials from plant biodiversity, with potential applications in pharmaceutical and cosmetic fields. Lipid-based nanoencapsulation stands out for its efficiency, ease of production, and versatility in encapsulating substances, whether hydrophilic or lipophilic. This work [...] Read more.
Encapsulation and drying technologies allow the engineering of innovative raw materials from plant biodiversity, with potential applications in pharmaceutical and cosmetic fields. Lipid-based nanoencapsulation stands out for its efficiency, ease of production, and versatility in encapsulating substances, whether hydrophilic or lipophilic. This work aimed at encapsulating pequi oil in liposomes and freeze-dried liposomes to enhance its stability and functional benefits, such as skin hydration and anti-aging effects, for use in innovative cosmetic formulations. Pequi oil—extracted from the Caryocar brasiliense fruit pulp, a plant species from Brazilian plant biodiversity—is rich in secondary metabolites and fatty acids. Liposomes and dried liposomes offer controlled production processes and seamless integration into cosmetic formulations. The physicochemical analysis of the developed liposomes confirmed that the formulations are homogeneous and electrokinetically stable, as evidenced by consistent particle size distribution and zeta potential values, respectively. The gel-type formulations loaded with the dried liposomes exhibit enhanced skin hydration, improved barrier function, and refined microrelief, indicating improvements in skin conditions. These results highlight the potential of dried liposomes containing pequi oil for the development of innovative cosmeceutical products. This research contributes to the valorization of Brazilian biodiversity by presenting an innovative approach to leveraging the dermatological benefits of pequi oil in cosmetic applications. Full article
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