Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.9
4.9
Journals
Pharmaceutics
Special Issues
Therapeutic Approaches for Wound-Associated Skin Diseases
share announcement

Therapeutic Approaches for Wound-Associated Skin Diseases

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 19710

Special Issue Editors

Prof. Dr. Lingjuan Zhang

E-Mail Website
Guest Editor
State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361002, China
Interests: dermal adipocytes; fibroblasts; innate immunity; inflammation; skin wound healing
Prof. Dr. Jiang Wu

E-Mail Website
Guest Editor
School of Pharmaceutical Sciences, Wenzhou Medical University, University-Town, Wenzhou 3251000, China
Interests: wound healing; materials biology; biomedical materials

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our Special Issue “Therapeutic Approaches for Wound-Associated Skin Diseases” of Pharmaceutics.

The skin, posied at the interface between our body and the environment, is constantly exposed to pathogens, toxins, allergens and mechanical insults. Upon skin injury, a highly orchestrated program of wound healing, which consists of hemostasis, inflammation, proliferation and remodeling, is rapidly initiated. The dysregulation of any stage of the wound healing process may lead to the pathogenesis of several wound healing disorders, such as chronic wounds, hypertrophic scars and keloids, which affect more than 100 million patients world-wide without effective non-invasive treatment options. In addition, inflammatory skin diseases, such as psoriasis and vasculitis, are often triggered by injury to the skin. Therefore, the development of new therapeutic approaches for wound healing, skin regeneration, and inflammation resolution is urgently needed.

This Special Issue aims to highlight up-to-date knowledge and progress in therapeutic approaches for wound-related skin disorders, such as non-healing/inflammatory wounds (e.g., chronic wounds and diabetic wounds), fibrosis (e.g., hypertrophic scars and keloids), skin infections and wound-triggered inflammatory skin diseases (e.g., psoriasis and vasculitis).

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but not limited to) the following:

  1. New drug development or biologics, delivery systems and target therapeutics for wound healing or wound-related diseases;
  2. Establishment of a wound-related skin disorder model, demonstrating the effectiveness of this model for therapeutic study;
  3. Novel detection methods or technologies for wound-related disease or wound healing;
  4. Discovery of new mechanisms underlying an established drug or therapy for wound-related skin disorders.

We look forward to receiving your contributions.

Prof. Dr. Lingjuan Zhang
Prof. Dr. Jiang Wu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wound healing
  • skin regeneration
  • chronic wounds
  • skin fibrosis
  • scarring
  • inflammation
  • drug delivery

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

22 pages, 2493 KiB  
Article
Hydrogels of Poly(2-hydroxyethyl methacrylate) and Poly(N,N-dimethylacrylamide) Interpenetrating Polymer Networks as Dermal Delivery Systems for Dexamethasone
by Marin Simeonov, Bistra Kostova, Rositsa Mihaylova and Elena Vassileva
Pharmaceutics 2025, 17(1), 62; https://doi.org/10.3390/pharmaceutics17010062 - 5 Jan 2025
Cited by 1 | Viewed by 826
Abstract
Background/Objectives: This study is an attempt to reveal the potential of two types of interpenetrating polymer network (IPN) hydrogels based on poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(N,N-dimethylacrylamide) (PDMAM). These IPNs were evaluated for their potential for dermal delivery of the hydrophobic drug dexamethasone [...] Read more.
Background/Objectives: This study is an attempt to reveal the potential of two types of interpenetrating polymer network (IPN) hydrogels based on poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(N,N-dimethylacrylamide) (PDMAM). These IPNs were evaluated for their potential for dermal delivery of the hydrophobic drug dexamethasone (DEX). Methods: The two types of IPNs were analyzed for their rheological behavior, swelling characteristics, and drug-loading capacity with DEX. Drug release profiles were studied in Franz diffusion cells in PBS media. Finally, the cytotoxicity of the PHEMA/PDMAM-based IPNs was studied against T-cell lymphoma cells (HUT-78) and a normal murine fibroblast cell line (CCL-1). Results: The rheological properties of these hydrogels show suitable mechanical properties for dermal application, with G′ values of ~10 kPa. From the rheological data, the mesh size of these hydrogels was found to be influenced by the type of the IPN and its composition, varying between 6.5 and 50 nm. The loading capacity of both IPN types and DEX entrapment efficiency were highly influenced by the IPN’s composition. The loading capacity of the IPNs can reach ~3.5%, with a DEX entrapment efficiency of ~35%. The PHEMA/PDMAM IPNs demonstrate an extended release profile with up to ~95% DEX released in 24 h, while PDMAM/PHEMA IPNs release no more than ~25% DEX in 24 h. The drug release profiles follow either non-Fickian diffusion (n~0.6) or case-II transport (n~0.9–1), depending on the IPN’s composition. The PHEMA/PDMAM-based materials were found to be non-cytotoxic against HUT-78 and CCL-1 cells. Conclusions: The study reveals that the IPNs of PHEMA and PDMAM appear to be suitable platforms for dermal delivery of dexamethasone as they have appropriate mechanical properties, providing tools to control drug loading and release, and they are biocompatible with human skin cells. Full article
(This article belongs to the Special Issue Therapeutic Approaches for Wound-Associated Skin Diseases)
►▼ Show Figures

Figure 1

19 pages, 7749 KiB  
Article
Targeted Antibacterial Endolysin to Treat Infected Wounds on 3D Full-Thickness Skin Model: XZ.700 Efficacy
by Marisa Meloni, Bob de Rooij, Ferdinand W. Janssen, Francesca Rescigno and Bernadette Lombardi
Pharmaceutics 2024, 16(12), 1539; https://doi.org/10.3390/pharmaceutics16121539 - 1 Dec 2024
Viewed by 1611
Abstract
Backgrounds/Objectives: Skin wound healing is a physiological process orchestrated by epithelial and mesenchymal cells able to restore tissue continuity by re-organizing themselves and the ECM. This research study aimed to develop an optimized in vitro experimental model of full-thickness skin, to address molecular [...] Read more.
Backgrounds/Objectives: Skin wound healing is a physiological process orchestrated by epithelial and mesenchymal cells able to restore tissue continuity by re-organizing themselves and the ECM. This research study aimed to develop an optimized in vitro experimental model of full-thickness skin, to address molecular and morphological modifications occurring in the re-epithelization and wound healing process. Methods: Wound healing starting events were investigated within an experimental window of 8 days at the molecular level by gene expression and immunofluorescence of key epidermal and dermal biomarkers. To mirror the behavior of infected wounds, the established wound healing model was then colonized with S. aureus, and the efficacy of a novel antibacterial agent, XZ.700, was investigated. Viable counts (CFU/tissue), IF, and ultrastructural analysis (SEM) were performed to evaluate S. aureus colonization inside and around the wound bed in an experimental window of 3 h of colonization and 24 h of treatment. Results: Endolysin showed an efficacy in counteracting bacterial growth and invasion within the wound bed, reducing the S. aureus load compared to its placebo, thanks to its selective antimicrobial activity interfering with biofilm formation. Conclusions: The preclinical in vitro infected wound model on FT-kin showed interesting applications to assess the repair efficacy of dermo-pharmaceutical and cosmetic formulations. Full article
(This article belongs to the Special Issue Therapeutic Approaches for Wound-Associated Skin Diseases)
►▼ Show Figures

Figure 1

Review

Jump to: Research

23 pages, 4435 KiB  
Review
Harnessing Cannabis sativa Oil for Enhanced Skin Wound Healing: The Role of Reactive Oxygen Species Regulation
by Dipa K. Israni, Neha R. Raghani, Jhanvi Soni, Mansi Shah, Bhupendra G. Prajapati, Mehul R. Chorawala, Supachoke Mangmool, Sudarshan Singh and Chuda Chittasupho
Pharmaceutics 2024, 16(10), 1277; https://doi.org/10.3390/pharmaceutics16101277 - 30 Sep 2024
Cited by 7 | Viewed by 4350
Abstract
Cannabis sativa emerges as a noteworthy candidate for its medicinal potential, particularly in wound healing. This review article explores the efficacy of cannabis oil in reducing reactive oxygen species (ROS) during the healing of acute and chronic wounds, comparing it to the standard [...] Read more.
Cannabis sativa emerges as a noteworthy candidate for its medicinal potential, particularly in wound healing. This review article explores the efficacy of cannabis oil in reducing reactive oxygen species (ROS) during the healing of acute and chronic wounds, comparing it to the standard treatments. ROS, produced from various internal and external sources, play a crucial role in wound development by causing cell and tissue damage. Understanding the role of ROS on skin wounds is essential, as they act both as signaling molecules and contributors to oxidative damage. Cannabis oil, recognized for its antioxidant properties, may help mitigate oxidative damage by scavenging ROS and upregulating antioxidative mechanisms, potentially enhancing wound healing. This review emphasizes ongoing research and the future potential of cannabis oil in dermatological treatments, highlighted through clinical studies and patent updates. Despite its promising benefits, optimizing cannabis oil formulations for therapeutic applications remains a challenge, underscoring the need for further research to realize its medicinal capabilities in wounds. Full article
(This article belongs to the Special Issue Therapeutic Approaches for Wound-Associated Skin Diseases)
►▼ Show Figures

Graphical abstract

13 pages, 966 KiB  
Review
Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy
by Katarzyna Witkowska, Magdalena Paczkowska-Walendowska, Ewa Garbiec and Judyta Cielecka-Piontek
Pharmaceutics 2024, 16(10), 1252; https://doi.org/10.3390/pharmaceutics16101252 - 26 Sep 2024
Cited by 3 | Viewed by 11797
Abstract
Centella asiatica, widely known as Gotu kola, is a traditional herb celebrated for its benefits in skin health and wound healing. Recent research has provided new insights into its efficacy, particularly through topical applications. This review highlights the plant’s mechanisms, focusing [...] Read more.
Centella asiatica, widely known as Gotu kola, is a traditional herb celebrated for its benefits in skin health and wound healing. Recent research has provided new insights into its efficacy, particularly through topical applications. This review highlights the plant’s mechanisms, focusing on its active compounds such as asiaticoside, madecassoside, asiatic acid, and madecassic acid, which enhance collagen synthesis, modulate inflammation, and offer antioxidant protection. Clinical trials have been collected and summarized that innovative delivery systems, such as hydrogels, nanostructures or microneedles, can accelerate wound healing, reduce wound size, and improve recovery times in various wound types, including diabetic ulcers and burns. Future research will likely refine these technologies and explore new applications, reinforcing the role of C. asiatica in contemporary wound care. Advances in formulation and delivery will continue to enhance the plant’s therapeutic potential, offering promising solutions for effective wound management. Full article
(This article belongs to the Special Issue Therapeutic Approaches for Wound-Associated Skin Diseases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop