Polymeric Nanoparticles for Pharmaceutical Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 1641

Special Issue Editor


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Guest Editor
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga 2752, Porto Alegre 90610-000, RS, Brazil
Interests: nanotechnology; drug delivery; cancer; immune system

Special Issue Information

Dear Colleagues,

In recent years, interest in using polymeric nanoparticles for drug delivery in pharmaceuticals has surged. These nanoparticles offer a versatile approach, comprising biocompatible and biodegradable polymers designed to encapsulate drugs. Upon administration, they enable controlled release and targeted delivery, overcoming barriers like poor solubility and enzymatic degradation. Their surface properties can be tailored for specific interactions with biological targets, minimizing off-target effects. Additionally, polymeric nanoparticles sustain drug release, improving patient compliance. By adjusting their characteristics, researchers enhance drug delivery efficiency.

This Special Issue will include research and reviews on polymeric nanoparticles' pharmaceutical applications and we invite researchers and drug developers to contribute original articles, thereby advancing drug delivery systems and therapeutics.

Dr. Luiza Abrahão Frank
Guest Editor

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Keywords

  • nanotechnology
  • polymeric nanoparticle
  • drug delivery
  • controlled release
  • therapeutic efficacy

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Published Papers (1 paper)

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Research

29 pages, 5553 KiB  
Article
Production of Prophylactic Nanoformulation for Dental Caries and Investigation of Its Effectiveness by In Vitro and In Silico Methods
by Yasemin Budama-Kilinc, Ozan Baris Kurtur, Bahar Gok, Serda Kecel-Gunduz, Sengul Alpay-Karaoglu, Pınar Yılmaz Atalı and Murat Kartal
Pharmaceutics 2025, 17(2), 167; https://doi.org/10.3390/pharmaceutics17020167 - 27 Jan 2025
Viewed by 1072
Abstract
Background/Objectives: This study aimed to develop cinnamon bark essential oil (CEO), orange peel essential oil(OEO) and the combination of these two essential oils (OEO-CEO) loaded PLGA nanoparticles to prevent dental caries and to investigate their effectiveness in silico and in vitro methods. Methods: [...] Read more.
Background/Objectives: This study aimed to develop cinnamon bark essential oil (CEO), orange peel essential oil(OEO) and the combination of these two essential oils (OEO-CEO) loaded PLGA nanoparticles to prevent dental caries and to investigate their effectiveness in silico and in vitro methods. Methods: EO loaded PLGA nanoparticles were produced by single emulsion method. Detailed characterization studies were performed using different methods, and the controlled release profile was obtained. The antibacterial activity of the developed formulations was investigated on S. mutans and L. casei strains by in vitro and in silico methods. Additionally, the interaction mechanisms of EOs with DNA were evaluated. Results: Our findings showed that the average droplet size of EO-loaded PLGA nanoparticles varied between 243.1 ± 0.60 nm and 219 ± 4.49 nm, while PdI values varied between 0.069 ± 0.039 and 0.032 ± 0.01. In addition, the developed nanoparticles had high encapsulation efficiency (85.14% to 66.28%) and released the active ingredient in a continuous and controlled manner. Ames test showed that the genotoxicity of EOs was eliminated due to the encapsulation of EOs in PLGA nanoparticles and antibacterial tests showed that OEO-CEO-loaded PLGA nanoparticles were effective on L. casei and S. mutans. The antibacterial activity of EOs was also supported by in silico studies. Finally, it was revealed that EOs showed potential as antibacterial agents by interacting with DNA. Conclusions: The results showed that OEO-CEO-loaded PLGA nanoparticles have the potential to be a suitable nanoformulation for developing mouthwash or toothpaste for the prevention and treatment of dental caries. Full article
(This article belongs to the Special Issue Polymeric Nanoparticles for Pharmaceutical Applications)
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