Recent Advances in Physiologically Based Biopharmaceutics Modeling
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".
Deadline for manuscript submissions: 25 June 2026 | Viewed by 1788
Special Issue Editor
Special Issue Information
Dear Colleagues,
The quantitative prediction of the pharmacokinetics, especially the absorption kinetics, of orally administered drugs has been investigated by many researchers. However, oral absorption is an amalgamation of many disciplines, including pharmacokinetics, formulation science, the physical chemistry of drugs, and physiology in the gastrointestinal tract of humans; research that achieves accurate prediction is still in its infancy. Needless to say, physiologically based biopharmaceutics modeling (PBBM) has attracted attention in the field of pharmaceutics in recent years as an approach to solving this problem. It is important to understand the benefits and current challenges of PBBM by having many case studies presented in a journal.
This Special Issue focuses on PBBM research in drug product development and clinical development. This Special Issue will include modeling and simulation approaches to forecast or evaluate the relative BA and BE between drug formulations, modeling approaches to predict the effects of food ingestion and concomitant medications on drug absorption, as well as studies discussing the relationship between drug formulation quality (such as API particle size and dissolution test specifications) and PBBM. It is hoped that this Special Issue will lead to the appropriate scientific use of PBBM and patient-centered drug development and drug approval review.
Dr. Atsushi Kambayashi
Guest Editor
Manuscript Submission Information
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Keywords
- oral drug absorption
- bioavailability
- bioequivalence
- modeling and simulation
- physiologically based biopharmaceutics modeling
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