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Pharmaceutics
Special Issues
Innovative Dosage Forms for Esophageal Drug Delivery
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Innovative Dosage Forms for Esophageal Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (20 January 2025) | Viewed by 2844

Special Issue Editors

Prof. Dr. Werner Weitschies

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Guest Editor
Department of Biopharmaceutics and Pharmaceutical Technology, Institute of Pharmacy, University of Greifswald, Felix-Hausdorff-Str. 3, 17489 Greifswald, Germany
Interests: oral drug delivery; biopharmaceutics; pharmakokinetics
Special Issues, Collections and Topics in MDPI journals
Dr. Julius Krause

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Guest Editor
Department of Biopharmaceutics and Pharmaceutical Technology, Institute of Pharmacy, University of Greifswald, Felix-Hausdorff-Str. 3, 17489 Greifswald, Germany
Interests: oral drug delivery; biopharmaceutics; pharmakokinetics; 3d printing
Dr. Christoph Rosenbaum

E-Mail Website
Guest Editor
Department of Biopharmaceutics and Pharmaceutical Technology, Institute of Pharmacy, University of Greifswald, Felix-Hausdorff-Str. 3, 17489 Greifswald, Germany
Interests: oral drug delivery; biopharmaceutics; pharmakokinetics

Special Issue Information

Dear Colleagues,

The increasing clinical interest in advanced and innovative delivery systems for targeted therapy of the esophagus is driven by the rising prevalence of several diseases such as esophagitis, GERD, Barrett’s esophagus and esophageal cancer in recent years. Addressing this demanding therapeutic challenge requires not only advances in formulation and device development, but also the advancement of modern pharmaceutical processes and technical solutions to enable precise biopharmaceutical causal drug targeting. The development of novel test methods for the pharmacokinetic and pharmacodynamic evaluation of new therapeutic concepts for the esophagus is also of great interest for this issue.

As guest editors, we invite researchers to submit their work for the Special Issue of Pharmaceutics entitled “Innovative Dosage Forms for Esophageal Drug Delivery”, which will address all multidisciplinary approaches that contribute to overcoming the complex challenge of targeted pharmacotherapy in the esophagus. Both research papers and reviews are welcome for publication.

We look forward to receiving your contributions.

Prof. Dr. Werner Weitschies
Dr. Julius Krause
Dr. Christoph Rosenbaum
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • esophagus
  • drug targeting
  • advanced drug delivery
  • esophagitis
  • gastroesophageal reflux disease
  • barrett’s esophagus
  • esophageal cancer
  • biorelevant dissolution

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Published Papers (1 paper)

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Research

13 pages, 1953 KiB  
Article
Modification of the Biorelevant Release Testing of Esophageal Applied Mucoadhesive Films and Development of Formulation Strategies to Increase the Mucosal Contact Time
by Friederike Brokmann, Paul Simonek and Christoph Rosenbaum
Pharmaceutics 2024, 16(8), 1021; https://doi.org/10.3390/pharmaceutics16081021 - 1 Aug 2024
Viewed by 2315
Abstract
The increasing prevalence of esophageal disease highlights the clinical relevance of novel, long-lasting mucoadhesive oral dosage forms. The EsoCap device enables targeted local application of films in the esophagus. Biorelevant test systems such as EsoPeriDiss are essential for early formulation development. To this [...] Read more.
The increasing prevalence of esophageal disease highlights the clinical relevance of novel, long-lasting mucoadhesive oral dosage forms. The EsoCap device enables targeted local application of films in the esophagus. Biorelevant test systems such as EsoPeriDiss are essential for early formulation development. To this end, the developed and already described release model for simulating the esophagus is being further developed for its potential for biorelevant mapping of the application site through complete tempering and investigation of biorelevant release media. Particularly viscous saliva formulations led to an extension of the retention time. In addition, possible formulation strategies for increasing the retention time of esophageal applied films are being evaluated, such as different film thicknesses, polymer grades and the influence of different active ingredient properties on the retention time. For highly soluble active ingredients, the film thickness represents an option for extending the retention time, while for less soluble substances, the choice of polymer grade may be of particular interest. Full article
(This article belongs to the Special Issue Innovative Dosage Forms for Esophageal Drug Delivery)
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