Nanoparticulate Systems for Nose-to-Brain Drug Delivery
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".
Deadline for manuscript submissions: closed (20 December 2023) | Viewed by 9529
Special Issue Editors
Interests: novel drug delivery systems; nanotechnology; solubility enhancement; targeted delivery; quality by design
Interests: nanotechnology in drug delivery systems; solubilization enhancement technologies; preformulation and material characterization; film-based drug delivery systems
Special Issue Information
Dear Colleagues,
The major barriers for the delivery of drugs to the central nervous system are the blood–brain barrier and blood–cerebrospinal fluid barrier which restrict most of the molecules entering the brain. In contrast, the direct nose-to-brain drug delivery system is a safe, feasible, mostly non-invasive, and convenient form of formulation approaches that could be considered an effective strategy, particularly for low molecular weight and macromolecular neurotherapeutics. Presently various strategies and approaches especially using nanoparticulate systems for enhanced nose-to-brain drug and biomolecule delivery have been investigated and have shown immense potential. Rapid advancement is expected in the field of specifically designed novel nanocarrier-based drug delivery systems to overcome different barriers for targeted drug delivery to the brain microenvironments. Moreover, combinatorial strategies have also been proved a very promising approach. Furthermore, focusing on the technological advances taking place in the development of novel drug delivery devices for intranasal administration is significant for brain targeting through the nose. Toxicological and regulatory aspects of various ingredients used to develop direct nose-to-brain drug delivery vehicles are a matter of paramount importance. Recent patents and the current clinical status of the potential neurotherapeutics with diverse pharmaceutical and biomedical applications should be highlighted.
This Special Issue will highlight recent advances and challenges encountered during the development of nanoparticulate drug delivery approaches and novel drug administration devices for the treatment of neurological conditions.
Prof. Dr. Jigar N. Shah
Prof. Dr. Shery Jacob
Guest Editors
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Keywords
- nanoparticles
- drug delivery
- brain targeting
- polymers
- in vitro release
- in vivo study
- nasal route
- penetration enhancer
- neurotherapeutics
- bioadhesion
- blood–brain barrier
- neuro-ailments
- neurological disorders
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