Microneedles for Transdermal Delivery and Diagnostic Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 1030

Special Issue Editor


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Guest Editor
Division of Pharmacoengineering and Molecular Pharmaceutics (DPMP), Center for Nanotechnology in Drug Delivery (CNDD), University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Interests: biomaterials; additive manufacturing; drug delivery

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to the upcoming Pharmaceutics Special Issue entitled “Microneedles for Transdermal Delivery and Diagnostic Applications”.

Microneedle technologies have rapidly evolved as promising platforms for minimally invasive transdermal delivery and biosensing. This Special Issue aims to highlight recent progress in microneedles’ potential in drug and vaccine delivery, diagnostics, and personalized medicine.

We welcome both original research articles and comprehensive reviews covering all aspects of microneedle technology. Topics of interest include, but are not limited to, the following:

  • Sustained, active, or sequential drug delivery systems;
  • Microneedle platforms for interstitial fluid sampling and real-time diagnostics;
  • Additive manufacturing and advanced microfabrication of microneedle systems;
  • Integration of microneedles with wearable or electronic platforms;
  • Delivery of biologics, nucleic acids, or cell-based therapeutics;
  • Microneedles for dermatologic or localized treatment applications;
  • Mechanical performance, modeling, and insertion behavior of microneedles;
  • Translational, manufacturing, and regulatory aspects of microneedle technologies.

We look forward to receiving your valuable contributions to this Special Issue and to showcasing the most recent advances in this rapidly expanding field.

Dr. Jillian L. Perry
Guest Editor

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Keywords

  • microneedles
  • transdermal delivery
  • biologic delivery
  • biosensing
  • interstitial fluid sampling
  • smart/bioresponsive
  • sustained release
  • controlled release
  • active drug delivery
  • sequential release
  • wearable devices
  • microfluidics

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Published Papers (1 paper)

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Research

26 pages, 23617 KB  
Article
Comparative Evaluation of Hydrogel Dip-Coating on Cone and Pyramid Microneedle Arrays Fabricated by LCD 3D Printing
by Feria Hasanpour, Oliwia Kordyl, Zuzanna Styrna, Barbara Jadach, Tomasz Osmałek, Ferhan Ayaydin, Mária Budai-Szűcs, Anita Kovács and Szilvia Berkó
Pharmaceutics 2026, 18(5), 518; https://doi.org/10.3390/pharmaceutics18050518 - 24 Apr 2026
Viewed by 656
Abstract
Background: Additive manufacturing provides a rapid and flexible alternative to conventional micromolding for producing microneedle systems. This study evaluates the potential of a cost-effective LCD 3D printer for fabricating microneedle arrays (MNAs) and investigates how the geometry of MNAs and the formulation [...] Read more.
Background: Additive manufacturing provides a rapid and flexible alternative to conventional micromolding for producing microneedle systems. This study evaluates the potential of a cost-effective LCD 3D printer for fabricating microneedle arrays (MNAs) and investigates how the geometry of MNAs and the formulation of hydrogel influence the performance of lidocaine-coated arrays. Methods: Conical and pyramidal MNAs, along with a reservoir plate, were designed and manufactured. Lidocaine-loaded and placebo hydrogels with two different polymer concentrations were prepared for dip-coating using both single and multilayer applications. Mechanical resistance and insertion efficiency were evaluated under controlled compression. The physicochemical behavior of the hydrogels were characterized, including pH, spreadability, adhesiveness, and rheological behavior. The uniformity of the coating was analyzed using 3D confocal microscopy. Drug loading was quantified by HPLC, drug release was studied using Franz diffusion cells, and skin penetration was confirmed by 3D confocal imaging and Raman mapping. Results: Conical microneedles exhibited high mechanical integrity, showing only a 2% reduction in height compared to 4% for pyramidal MNAs. Stronger drug signals were achieved in deeper skin layers with the conical geometry, indicating enhanced penetration, while pyramidal MNAs provided slightly higher lidocaine loading due to their larger lateral surface. Hydrogels with higher polymer content produced more stable, uniform coatings, particularly when applied in three layers. Rapid drug release was observed, with over 70% of the drug delivered within minutes. Conclusions: LCD 3D printing offers a cost-effective approach for fabricating MNAs with suitable structural stability and sharpness. The optimized hydrogel formulation ensured uniform coverage, as well as maximal and consistence penetration, making this platform a promising candidate for the dermal delivery of other potent drugs. Full article
(This article belongs to the Special Issue Microneedles for Transdermal Delivery and Diagnostic Applications)
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