Nano-Drug Delivery Systems for Targeting the Tumor Microenvironment and Simultaneously Overcoming Drug Resistance Properties
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: 20 May 2024 | Viewed by 1856
Special Issue Editors
Interests: cancer cell metabolism; multidrug resistance in cancer cells; Pgp activity; pH regulators in cancer; new anticancer drugs
Special Issues, Collections and Topics in MDPI journals
2. 1H-TOXRUN—One Health Toxicology Research Unit, University Institute of Health Sciences, CESPU, CRL, 4585-116 Gandra, Portugal
Interests: anticancer strategies; targeted therapy; cancer biomarkers; mitosis; apoptosis; drug discovery; bioactive compounds
Special Issue Information
Dear Colleagues,
Cancer is a complex disease and one of the most profound challenges to human health. Although new and innovative therapies have emerged throughout the years, the battle against cancer is often lost, with the treatment becoming ineffective and the disease recurring. One of the major obstacles in this fight is the resistance, innate or acquired, developed by cancer cells against the drugs commonly used in chemotherapy. Multidrug resistance, often abbreviated as MDR, is defined as a phenotype, intrinsic or developed during the treatment, where cells are resistant to multiple drugs with no obvious structural similarities and with different molecular targets. Different mechanisms can be involved in MDR, from intracellular adaptations (e.g., the expression of Pgp) to tumour microenvironment (TME) characteristics.
Endogenous stimulus-responsive nanosystems were developed based on the pathophysiological characteristics of the endogenous tumor microenvironment and have emerged as an effective cancer treatment, playing an increasingly important role in combating cancer drug resistance. These nanodrug delivery systems provide flexible and effective methods to overcome multidrug resistance by promoting cellular uptake, increasing drug accumulation, reducing drug efflux, improving targeted drug delivery, co-administering synergistic drugs, and increasing drugs’ half-life in the circulation, thereby improving the effectiveness of cancer treatment.
In this Special Issue, we aim to collect reviews or original manuscripts covering nanosystems with endogenous stimulus-responsive characteristics to overcome MDR and discussing their antitumor effects in vitro and in vivo.
Dr. Odília Queirós
Dr. Patrícia M. A. Silva
Guest Editors
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Keywords
- cancer therapy
- multidrug resistance
- mechanisms of drug resistance
- tumor microenvironment
- ABC transporters
- combined therapy
- drug delivery