Nano-Drug Delivery Systems: Tackling Cancer Metabolism and Drug Resistance
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 7
Special Issue Editor
Interests: cancer cell metabolism; multidrug resistance in cancer cells; Pgp activity; pH regulators in cancer; new anticancer drugs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer remains a leading cause of mortality worldwide, with therapeutic resistance and metabolic plasticity posing major challenges to effective treatment. This Special Issue focuses on the development and application of nano-drug delivery systems designed to target cancer metabolism and overcome drug resistance mechanisms. Nanotechnology offers unique advantages, such as targeted delivery, improved bioavailability, and controlled release, that can enhance the efficacy of anticancer agents while minimizing systemic toxicity. Of particular interest are nanosystems that disrupt metabolic pathways like glycolysis, glutaminolysis, and oxidative phosphorylation, or that modulate the tumor microenvironment to sensitize resistant cancer cells to therapy.
We invite original research articles, reviews, and short communications that explore innovative nanocarriers, combination strategies, and preclinical or clinical advances in this field. By integrating nanotechnology with a deep understanding of tumor biology, this Special Issue aims to pave the way for next-generation therapies that effectively combat cancer progression and treatment resistance.
Dr. Odília Queirós
Guest Editor
Manuscript Submission Information
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Keywords
- nano-drug delivery systems
- tumor microenvironment
- cancer metabolism
- metabolic reprogramming
- drug resistance
- targeted therapy
- combination therapy
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