Biocompatible Liposomes for Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 15 September 2026 | Viewed by 1272

Special Issue Editors


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Guest Editor
Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary
Interests: nose-to-brain delivery; nanomedicine; albumin nanoparticles; polymeric micelles; freeze-drying
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Guest Editor
Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis Str. 6, 6725 Szeged, Hungary
Interests: liposomes; liposomal encapsulation; chlamydia; herpes viruses; sexually transmitted infections; drug delivery; antibiotic resistance

Special Issue Information

Dear Colleagues,

One of the greatest challenges facing modern medicine is the targeted, safe, and effective delivery of active ingredients into the body. In recent years, biocompatible liposomes—tiny spherical particles composed of naturally occurring phospholipids—have garnered enhanced attention in the field of drug delivery systems.

These nanoscopic “packaging” devices are capable of transporting both water-soluble and fat-soluble drug molecules. Their unique structure allows them to protect the active ingredient from degradation and deliver it directly to the desired cells or tissues, such as cancer cells or inflammatory areas. In addition, their potentiating effect in cases of infection is also significant.

Biocompatibility means that the components of liposomes do not trigger an immune response and do not harm the body during their degradation, making them ideal for long-term therapeutic use.

Current research is focused on developing liposome systems that are capable of

  • increasing the stability and bioavailability of drugs,
  • reducing side effects, and
  • adapting to individual therapeutic needs.

This technology offers new opportunities not only in cancer therapy or the treatment of infections, but also in the drug therapy of inflammatory, autoimmune, or neurological diseases.

Biocompatible liposomes are therefore not just a laboratory curiosity, but represent a real opportunity to make the therapies of the future more personalized, effective, and safe.

This Special Issue of Pharmaceutics welcome the submission of reviews and original articles that demonstrate the use of biocompatible liposomes in various fields of medicine.

Dr. Katona Gábor
Dr. Anita Bogdanov
Guest Editors

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Keywords

  • liposome
  • biocompatible liposomes
  • drug delivery system
  • anti-cancer therapy
  • anti-inflammatory therapy
  • antibiotics

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Published Papers (1 paper)

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Research

18 pages, 7692 KB  
Article
Ultrasound-Sensitive Liposomal Exatecan for Tumor-Specific Drug Release for Treatment of Pancreatic Cancer
by Dongyeon Kim, Hyungwon Moon, Sunyoung Han and Hak Jong Lee
Pharmaceutics 2026, 18(1), 3; https://doi.org/10.3390/pharmaceutics18010003 - 19 Dec 2025
Cited by 1 | Viewed by 852
Abstract
Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers, largely due to its dense stromal architecture and poor intratumoral drug penetration. To address this challenge, IMP305 was developed as an ultrasound-sensitive liposome for tumor-localized drug release. In particular, IMP305 is [...] Read more.
Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers, largely due to its dense stromal architecture and poor intratumoral drug penetration. To address this challenge, IMP305 was developed as an ultrasound-sensitive liposome for tumor-localized drug release. In particular, IMP305 is dominantly capable of release by ultrasound-mediated cavitation. Methods: This ultrasound-sensitive liposome integrates tumor-specific drug delivery with cavitation-induced loosening of the stromal architecture in PDAC, thereby enabling more efficient intratumoral drug release using PANC-1 xenografted mouse. Results: The maximal tolerance dose of exatecan was increased by encapsulation into IMP305. Cavitation-triggered structural disruption of IMP305 was 84.68 ± 6.21%, which resulted in a robust release of approximately 84.4 ± 1.95% of the encapsulated exatecan. In PANC-1 xenograft models, IMP305 exhibited a maximal tolerance dose approximately four times higher than that of free exatecan and demonstrated markedly superior antitumor ability. Especially, IMP305 combined with focused ultrasound achieved the most pronounced therapeutic benefit, demonstrating a 49.17 ± 9.00% reduction in tumor volume at day 48 and an 80% survival rate at day 60. Conclusions: In conclusion, these findings demonstrate that ultrasound-activated IMP305 significantly enhances intratumoral accumulation and release of exatecan, resulting in superior tumor suppression while mitigating systemic toxicity. Full article
(This article belongs to the Special Issue Biocompatible Liposomes for Drug Delivery)
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