Recent Advances in Biomaterials for Wound Healing

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 3793

Special Issue Editors


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Guest Editor
Department of Chemical Engineering, Federal University of Ceará, Fortaleza 60455-760, Brazil
Interests: biomaterials; surface treatments; biopolymers; polymers; bioactivation of materials; physicochemical characterizations; dressings; advanced therapy
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Guest Editor
Northeast Strategic Technologies Center (CETENE), Recife 50740-540, Brazil
Interests: biomaterials; polymers; biopolymers; dressings; drug release; polymer modification; biomaterials interface; bioactivation of materials; cell culture; advanced therapy

Special Issue Information

Dear Colleagues,

Dressings serve as therapeutic aids in wound repair and constitute a crucial segment of the medical and pharmaceutical markets. Physiologically, wound repair is a natural and intricate biological progression, encompassing four distinct and consecutive phases: hemostasis, inflammation, cell proliferation, and tissue remodeling. The initiation of tissue regeneration and/or healing hinges upon various factors, primarily the magnitude and depth of the wound, alongside patient-specific factors such as age, diabetes, and obesity.

The efficient management of wound healing is imperative to prevent complications and deter the progression of wounds into chronic states. Therefore, the prudent application of dressings assumes a pivotal role, dynamically adjusting to the injury's intrinsic and extrinsic factors. An array of materials can be strategically engineered to serve as passive dressings, shielding the wound while modulating the physiological conditions conducive to tissue repair. Moreover, these materials can act as therapeutic agents via the incorporation of bioactive substances, including antimicrobial, anti-inflammatory, and debridement agents, or other functional compounds released locally to facilitate healing.

In this vein, the quest for biomaterials that are capable of expediting the healing process, particularly in chronic wounds, as well as aiding in the diagnosis and treatment of infected lesions, presents a formidable challenge that has spurred extensive research. The profound psychological, physical, and financial toll such wounds have on patients underscores the urgency of addressing these challenges.

This Special Issue aims to spotlight recent advancements in biomaterials that hold innovative promise in wound treatment and tissue repair.

Prof. Dr. Rodrigo Silveira Vieira
Dr. Niédja Fittipaldi Vasconcelos
Guest Editors

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Keywords

  • dressings
  • biomaterials
  • therapeutic agents
  • antimicrobial
  • anti-inflammatory
  • debridement
  • infected lesion
  • drug delivery
  • tissue regeneration
  • wound healing

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Published Papers (2 papers)

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Research

16 pages, 2175 KiB  
Article
Antibiofilm, Anti-Inflammatory, and Regenerative Properties of a New Stable Ozone-Gel Formulation
by Carla Russo, Giuseppe Curcio, Alessandro Graziani, Antonella Mencacci and Donatella Pietrella
Pharmaceutics 2024, 16(12), 1580; https://doi.org/10.3390/pharmaceutics16121580 - 11 Dec 2024
Cited by 1 | Viewed by 1381
Abstract
Background/Objectives: Chronic skin wounds are characterized by inflammation, persistent infections, and tissue necrosis. The presence of bacterial biofilms prolongs the inflammatory response and delays healing. Ozone is a potent antimicrobial molecule, and many formulations have been used in the advanced therapeutic treatment [...] Read more.
Background/Objectives: Chronic skin wounds are characterized by inflammation, persistent infections, and tissue necrosis. The presence of bacterial biofilms prolongs the inflammatory response and delays healing. Ozone is a potent antimicrobial molecule, and many formulations have been used in the advanced therapeutic treatment of chronic wounds. The aim of this work was to determine the antimicrobial, anti-inflammatory, and regenerative activity of a stable ozone-gel formulation over time. Methods: The antimicrobial property was assessed by measuring the minimal inhibitory concentration and the antibiofilm activity. The anti-inflammatory effect was evaluated by TNF-α determination, and the regenerative effect was measured by scratch assay. Results: The ozone gel demonstrated antimicrobial and antibiofilm activity in all ATCC microorganisms examined and on most clinical isolates. Higher concentrations of the ozone gel were also useful in the dispersion of preformed biofilm. The ozone gel also showed anti-inflammatory activity by reducing the production of TNF-α and regenerative activity in human fibroblasts and keratinocytes. Conclusions: Given all these antimicrobial, anti-inflammatory, and regenerative characteristics, the ozone gel could be, in this formulation, used in the treatment of wounds. The ozone-gel formulation described here retains stability for over 30 months, which facilitates its use compared to formulations that lose efficacy quickly. Full article
(This article belongs to the Special Issue Recent Advances in Biomaterials for Wound Healing)
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22 pages, 3767 KiB  
Article
Oxidized Bacterial Cellulose Membranes Immobilized with Papain for Dressing Applications: Physicochemical and In Vitro Biological Properties
by Niédja Fittipaldi Vasconcelos, Pascale Chevallier, Diego Mantovani, Morsyleide de Freitas Rosa, Fernando José Soares Barros, Fábia Karine Andrade and Rodrigo Silveira Vieira
Pharmaceutics 2024, 16(8), 1085; https://doi.org/10.3390/pharmaceutics16081085 - 18 Aug 2024
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Abstract
This research consolidates our group’s advances in developing a therapeutic dressing with innovative enzymatic debridement, focusing on the physicochemical and in vitro biological properties of papain immobilized in wet oxidized bacterial cellulose (OxBC–Papain) dressing. OxBC membranes were produced with Komagataeibacter hansenii oxidized with [...] Read more.
This research consolidates our group’s advances in developing a therapeutic dressing with innovative enzymatic debridement, focusing on the physicochemical and in vitro biological properties of papain immobilized in wet oxidized bacterial cellulose (OxBC–Papain) dressing. OxBC membranes were produced with Komagataeibacter hansenii oxidized with NaIO4, and papain was immobilized on them. They were characterized in terms of enzyme stability (over 100 days), absorption capacity, water vapor transmission (WVT), hemocompatibility, cytotoxicity, and cell adhesion. The OxBC–Papain membrane showed 68.5% proteolytic activity after 100 days, demonstrating the benefit of using the OxBC wet membrane for papain stability. It had a WVT rate of 678 g/m2·24 h and cell viability of 99% and 86% for L929 and HaCat cells, respectively. The membranes exhibited non-hemolytic behavior and maintained 26% clotting capacity after 1 h. The wet OxBC–Papain membrane shows significant potential as a natural biomolecule-based therapeutic dressing for wound care, offering efficient debridement, moisture maintenance, exudate absorption, gas exchange, and hemostasis without cytotoxic effects or cell adhesion to the dressing. Further research, especially using in vivo models, is needed to assess its efficacy in inducing epithelialization. This study advances stomatherapy knowledge, providing a cost-effective solution for enzymatic debridement in healthcare. Full article
(This article belongs to the Special Issue Recent Advances in Biomaterials for Wound Healing)
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