Bioactive Hydrogels as Multifunctional Dressing Materials

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 715

Special Issue Editors


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Guest Editor
Department of Biomedical Engineering, Institute of Material and Biomedical Engineering, Faculty of Engineering and Technical Sciences, University of Zielona Gora, Licealna 9 Street, 65-417 Zielona Gora, Poland
Interests: biomaterials and polymers in medicine; implants and artificial organs; biomechanics tissue and tissue engineering; regenerative medicine; numerical methods and simulations of biological systems

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Guest Editor
Department of Biomedical Engineering, Institute of Material and Biomedical Engineering, Faculty of Engineering and Technical Sciences, University of Zielona Gora, Licealna 9 Street, 65-417 Zielona Gora, Poland
Interests: polymers; FEA numerical analysis in biological systems; tissue damage mechanisms; body fluid flow

Special Issue Information

Dear Colleagues,

We are pleased to invite you to participate in a Special Issue entitled “Bioactive Hydrogels as Multifunctional Dressing Materials”, the aim of which is to present the current state of knowledge, prospects and limitations associated with hydrogel materials that can be successfully used as dressings for hard-to-heal wounds. Natural polymers, such as sodium alginate, chitosan or others, have properties that, especially for regenerative medicine and tissue engineering, are extremely valuable. The development and manufacture of hydrogels with pharmaceuticals can form the basis for the treatment and regeneration of hard-to-heal wounds, such as burns or bedsores. Diseases that attack the skin, accidents and surgical wounds are serious medical problems. The effectiveness of wound healing and regeneration can be improved by developing new multifunctional bioactive hydrogels. The development of the science of polymers and the technology for their manufacture and modification is a rapidly developing issue that could revolutionize the world of medicine. Particularly noteworthy are the mechanical and material properties of polymers that support tissue regeneration and reconstruction. Moreover, hydrogel materials can be excellent carriers of active substances or drugs, which further distinguishes them from other materials.

This Special Issue is dedicated to innovative research and developments in the field of polymer science and its application in biomedicine. We cordially invite all interested researchers to share their research results in original research articles and submit insightful review articles on the latest, groundbreaking scientific discoveries in the field of science.

Dr. Jagoda Kurowiak
Dr. Tomasz Klekiel
Guest Editors

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Keywords

  • biocompatible hydrogels
  • functional materials
  • natural polymers
  • biohydrogels
  • dressings
  • hard-to-heal wounds
  • burns
  • bedsores
  • pharmaceuticals
  • active substances
  • anti-inflammatory and antibacterial drugs

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Published Papers (1 paper)

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Research

16 pages, 15162 KiB  
Article
Facial Skin Density Enhancement Using Hyaluronic Acid—Based Bioactive Hydrogel: Cannula-Assisted Delivery and Ultrasound Evaluation in a Retrospective Controlled Study
by Lidia Majewska, Karolina Dorosz and Jacek Kijowski
Pharmaceutics 2025, 17(5), 553; https://doi.org/10.3390/pharmaceutics17050553 - 24 Apr 2025
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Abstract
Background: Hyaluronic acid (HA)–based bioactive hydrogels have emerged as multifunctional platforms for skin bioregeneration. While traditional mesotherapy using multicomponent substances has been widely practiced for improving skin quality, the time-consuming nature of this approach has led to exploration of alternative delivery methods. [...] Read more.
Background: Hyaluronic acid (HA)–based bioactive hydrogels have emerged as multifunctional platforms for skin bioregeneration. While traditional mesotherapy using multicomponent substances has been widely practiced for improving skin quality, the time-consuming nature of this approach has led to exploration of alternative delivery methods. Aims: This study evaluated the clinical effectiveness of an HA bioactive hydrogel-based bioregeneration system (containing non-stabilized hyaluronic acid and 14 bioactive ingredients) administered via cannula and its impact on facial skin density as assessed by ultrasound imaging. Methods: We conducted a retrospective review of data from 20 female patients aged 30–42 years who received a single cannula-delivered injection of a bioactive hyaluronic acid hydrogel (TEOSYAL® Redensity [I]) in the midface region. The formulation combines the structural benefits of hyaluronic acid with the biochemical stimulation provided by amino acids, antioxidants, minerals, and vitamins. Skin density was measured using high-frequency ultrasound at baseline, immediately post-procedure, and at 3–4 weeks follow-up. A control group of seven individuals received no treatment. Results: Ultrasound assessments revealed a statistically significant increase in skin density (92.7%, p < 0.001) within the treated area compared to no significant changes in the control group. This substantial improvement in dermal architecture demonstrates the efficacy of bioactive hydrogels in stimulating fibroblast function and extracellular matrix regeneration. Patient satisfaction was high, with 85% of patients reporting being satisfied or very satisfied. Side effects were minimal, with minor bruising (10%) and transient swelling (15%). Conclusions: Cannula-delivered bioactive hyaluronic acid hydrogel effectively enhances facial skin density with high patient satisfaction and minimal downtime, demonstrating the potential of advanced hydrogel formulations as multifunctional therapeutic platforms that extend beyond traditional applications into aesthetic and regenerative dermatology. Full article
(This article belongs to the Special Issue Bioactive Hydrogels as Multifunctional Dressing Materials)
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