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Pharmaceutics
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Polymeric and Thiolated Nanopharmaceuticals: Advances in Drug Delivery and Therapeutic...
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Polymeric and Thiolated Nanopharmaceuticals: Advances in Drug Delivery and Therapeutic Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (20 December 2024) | Viewed by 2355

Special Issue Editor

Dr. Sobia Noreen

E-Mail Website
Guest Editor
Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Punjab, Pakistan
Interests: nanomaterials; colon cancer; drug delivery; polymeric materials; mucoadhesion; thiolation; pharmaceutical drug development; controlled drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, entitled "Polymeric and Thiolated Nanopharmaceuticals: Advances in Drug Delivery and Therapeutic Applications", explores the cutting-edge innovations at the intersection of polymers, thiolated compounds, and nanopharmaceuticals. It delves into the forefront of drug delivery, presenting advanced formulations and strategies that have the potential to redefine therapeutic applications. From the design intricacies of polymeric carriers to the unique properties conferred by thiolation, it explores the potential of nanopharmaceuticals to revolutionize drug release mechanisms and enable targeted delivery. This Special Issue offers a comprehensive exploration of the latest breakthroughs, addressing challenges in drug delivery through novel formulations and controlled release techniques. It serves as a valuable resource for researchers and practitioners seeking a nuanced understanding of the evolving landscape of polymeric and thiolated nanopharmaceuticals. By providing a dedicated platform for researchers, this Special Issue aims to facilitate the exchange of knowledge on nanoparticle formulations, targeted drug delivery systems, nanomedicine, and nanotheranostics.

Dr. Sobia Noreen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymeric nanopharmaceuticals
  • thiolated drug delivery
  • nanomedicine
  • nanotheranostics
  • nanoparticle formulations
  • targeted drug delivery
  • nanotechnology in pharmacology
  • therapeutic nanosystems
  • pharmaceutical nanotechnology
  • polymeric nanotechnology

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Published Papers (1 paper)

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Research

24 pages, 5375 KiB  
Article
Preparation and Evaluation of pH-Sensitive Chitosan/Alginate Nanohybrid Mucoadhesive Hydrogel Beads: An Effective Approach to a Gastro-Retentive Drug Delivery System
by Sadia Rehman, Qazi Adnan Jamil, Sobia Noreen, Muhammad Azeem Ashraf, Asadullah Madni, Hassan Mahmood, Hina Shoukat and Muhammad Rafi Raza
Pharmaceutics 2024, 16(11), 1451; https://doi.org/10.3390/pharmaceutics16111451 - 13 Nov 2024
Viewed by 1717
Abstract
Background: Despite extensive research over the decades, cancer therapy is still a great challenge because of the non-specific delivery of chemotherapeutic agents, which could be overcome by limiting the distribution of chemotherapeutic agents toward cancer cells. Objective: To reduce the cytolytic effects against [...] Read more.
Background: Despite extensive research over the decades, cancer therapy is still a great challenge because of the non-specific delivery of chemotherapeutic agents, which could be overcome by limiting the distribution of chemotherapeutic agents toward cancer cells. Objective: To reduce the cytolytic effects against cancer cells, graphene oxide (GO) nanoparticles (NPs) can load anticancer medicines and genetic tools. Methodology: During the current study, folic-acid-conjugated graphene oxide (Fa-GO) hybrid mucoadhesive chitosan (CS)-based hydrogel beads were fabricated through an “ion-gelation process”, which allows for regulated medication release at malignant pH. Results: The fabricated chitosan–alginate (SA-CS) hydrogel beads were examined using surface morphology, optical microscopy, XRD, FTIR, and homogeneity analysis techniques. The size analysis indicated that the size of the Fa-GO was up to 554.2 ± 95.14 nm, whereas the beads were of a micrometer size. The folic acid conjugation was confirmed by NMR. The results showed that the craggy edges of the graphene oxide were successfully encapsulated in a polymeric matrix. The mucoadhesive properties were enhanced with the increase in the CS concentration. The nanohybrid SA-CS beads exhibited good swelling properties, and the drug release was 68.29% at pH 5.6 during a 24 h investigation. The accelerated stability study, according to ICH guidelines, indicated that the hydrogel beads have a shelf-life of more than two years. Conclusions: Based on the achieved results, it can be concluded that this novel gastro-retentive delivery system may be a viable and different way to improve the stomach retention of anticancer agents and enhance their therapeutic effectiveness. Full article
(This article belongs to the Special Issue Polymeric and Thiolated Nanopharmaceuticals: Advances in Drug Delivery and Therapeutic Applications)
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