Biopolymer Nanoparticles for Targeted Therapy in Cardiovascular Diseases

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 20 October 2026 | Viewed by 1657

Special Issue Editors


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Departamento de Ingeniería Genética, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Irapuato 36824, Mexico
Interests: nanobiotechnology; nanoparticles; multiphoton microscopy; electron microscopy; cell and tissues

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Guest Editor
Department of Medical Sciences, Division of Health Sciences, Leon Campus, University of Guanajuato, Leon 37320, Mexico
Interests: atherosclerosis; epigenetics; epigenomics; cardiovascular therapy; mouse models
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Special Issue Information

Dear Colleagues,

Nanotechnology is significantly impacting several areas of biology and pathology. In human health, the development of nanocarriers has improved diagnosis, pharmacology, and therapy. Nanocarriers based on biopolymers, dendrimers, and liposomes have revolutionized the administration of a number of drugs. On the other hand, the mechanisms underlying nanocarrier disassembling and payload deliver within cells remain, in some cases, unclear. Among diseases, cardiovascular disease (CVD) is the first cause of death and disability worldwide, accounting for 17.9 million lost lives yearly. CVD includes various disorders affecting the brain, heart, and blood vessels. This Special Issue will address novel nanopharmacological aspects that can be applied to treat the wide symptoms and causes of CVD. We invite articles on all topics related to the applications of biopolymer nanoparticles and novel drug-loaded nanostructures-based biopolymers applied to the treatment of CVD. This Special Issue focuses on the synthesis, physicochemical characterization, stability, delivery, targeting, and dissembling mechanisms of nanoparticles. In addition, the effect of nanoparticles loaded with drugs can be administrated to cells and tissues for in vitro growth, therapies, imaging diagnosis, and experimental treatments in murine models for CVD are accepted. Clinical studies in humans are accepted. Original research papers and review articles are welcome.

Dr. Lino Sánchez-Segura
Prof. Dr. Silvio Zaina
Guest Editors

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Keywords

  • nanoparticles
  • biopolymers
  • drug-load
  • drug delivery
  • target
  • cardiovascular disease
  • therapy

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Published Papers (1 paper)

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Research

17 pages, 17635 KB  
Article
Improvements of Blood Compatibility, Drug-in-Polymer Coating Stability and Prevention of Crack Formation: Application to Drug-Eluting Stents
by Tarek M. Bedair and Dong Keun Han
Pharmaceutics 2026, 18(4), 506; https://doi.org/10.3390/pharmaceutics18040506 - 20 Apr 2026
Viewed by 1096
Abstract
Background/Objectives: Commercially available drug-eluting stents still suffer from poor blood compatibility, polymer coating delamination, polymer cracking and lack of stability during and after stent implantation that led to adverse events such as stent thrombosis and in-stent restenosis. This article highlights the advantages [...] Read more.
Background/Objectives: Commercially available drug-eluting stents still suffer from poor blood compatibility, polymer coating delamination, polymer cracking and lack of stability during and after stent implantation that led to adverse events such as stent thrombosis and in-stent restenosis. This article highlights the advantages of using silicon nanofilament (SiNf) as an interface between stent surface and drug-in-polymer coating or bloodstream. Methods: Thin layer of SiNf was successfully formed on the surface of Co-Cr substrate via one-step simple method. For stent applications, sirolimus-in-poly(D,L-lactide) (PDLLA/SRL) matrix was coated on control and SiNf-modified Co-Cr substrates and the stability, cracking, and long-term degradation was compared. Blood compatibility studies were also compared between control and SiNf-modified Co-Cr substrates. Results: The morphology of the filaments showed nanosized structures with nano-gaps between the filaments which support mechanical interlocking of PDLLA/SRL coating and enhanced the coating stability with no coating delamination whereas, the control substrate presented 97% of coating delamination. The PDLLA/SRL coating on stent platform demonstrates smooth and uniform morphology without webbing between stent struts. After stent ballooning, the control stent presented cracking and peeling of the polymer coating from the surface whereas, the SiNf-modified stent did not show any signs of these unfavorable defects. Moreover, SiNf-modified surface showed reduced fibrinogen adsorption and lower number of platelet adhesion with round shape morphology. Conclusions: Overall, this suggests that modifying the metallic substrates with SiNf could act as a universal coating for reinforcing the polymer coating stability, prevent coating defects that accompany stent ballooning, and improve the blood compatibility of the material surfaces that could have various applications to medical implants and devices. Full article
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