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Pharmaceutics
Special Issues
Extracellular Vesicles for Targeted Delivery
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Extracellular Vesicles for Targeted Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biologics and Biosimilars".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1225

Special Issue Editor

Dr. Beáta Soltész

E-Mail Website
Guest Editor
Department of Human Genetics, Faculty of Medicine, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary
Interests: clinical application of liquid biopsy; exosomes; nucleic acids (e.g., gDNA, mtDNA, miRNA, and lncRNA) and cell-free nucleic acids; molecular biology; genetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Extracellular vesicles (EVs), mainly exosomes, are more applicable in the early detection, characterization, and monitoring of various diseases. EVs are packed with several molecules, which may affect cell-to-cell communication after release. Therefore, these are ideal candidates for delivering molecules such as nucleic acids, proteins, and designed drugs. The modified and engineered exosomes may become star delivery vehicles and the importance of these in therapy may be highlighted. We may gather worthwhile information from EVs to understand their role in the progression of distinct diseases and in treatment options as carrying cargo to the target cells. Several beneficial properties of EVs make them promising therapeutic shuttle vesicles, and therefore, personalized medicine made from engineered extracellular vesicles may be a new treatment option for various diseases.

This Special Issue aims to address the latest research or new views on extracellular vesicles in the monitoring, characterizing, and understanding of background mechanisms, and thus, possible therapeutic applications.

Dr. Beáta Soltész
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • computational approaches
  • drug delivery
  • engineered exosomes
  • exosomes
  • experimental approaches
  • extracellular vesicle-based delivery
  • extracellular vesicles
  • immunotherapy
  • nanomedicine
  • therapeutic cargo
  • therapy

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Published Papers (1 paper)

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Review

22 pages, 1826 KiB  
Review
Nanomanaging Chronic Wounds with Targeted Exosome Therapeutics
by Anita Yadav, Anu Sharma, Mohini Moulick and Subhadip Ghatak
Pharmaceutics 2025, 17(3), 366; https://doi.org/10.3390/pharmaceutics17030366 - 13 Mar 2025
Cited by 1 | Viewed by 940
Abstract
Chronic wounds pose a significant healthcare challenge, impacting millions of patients worldwide and burdening healthcare systems substantially. These wounds often occur as comorbidities and are prone to infections. Such infections hinder the healing process, complicating clinical management and proving recalcitrant to therapy. The [...] Read more.
Chronic wounds pose a significant healthcare challenge, impacting millions of patients worldwide and burdening healthcare systems substantially. These wounds often occur as comorbidities and are prone to infections. Such infections hinder the healing process, complicating clinical management and proving recalcitrant to therapy. The environment within the wound itself poses challenges such as lack of oxygen, restricted blood flow, oxidative stress, ongoing inflammation, and bacterial presence. Traditional systemic treatment for such chronic peripheral wounds may not be effective due to inadequate blood supply, resulting in unintended side effects. Furthermore, topical applications are often impervious to persistent biofilm infections. A growing clinical concern is the lack of effective therapeutic modalities for treating chronic wounds. Additionally, the chemically harsh wound microenvironment can reduce the effectiveness of treatments, highlighting the need for drug delivery systems that can deliver therapies precisely where needed with optimal dosages. Compared to cell-based therapies, exosome-based therapies offer distinct advantages as a cell-free approach for chronic wound treatment. Exosomes are of endosomal origin and enable cell-to-cell communications, and they possess benefits, including biocompatibility and decreased immunogenicity, making them ideal vehicles for efficient targeting and minimizing off-target damage. However, exosomes are rapidly cleared from the body, making it difficult to maintain optimal therapeutic concentrations at wound sites. The hydrogel-based approach and development of biocompatible scaffolds for exosome-based therapies can be beneficial for sustained release and prolong the presence of these therapeutic exosomes at chronic wound sites. Engineered exosomes have been shown to possess stability and effectiveness in promoting wound healing compared to their unmodified counterparts. Significant progress has been made in this field, but further research is essential to unlock their clinical potential. This review seeks to explore the benefits and opportunities of exosome-based therapies in chronic wounds, ensuring sustained efficacy and precise delivery despite the obstacles posed by the wound environment. Full article
(This article belongs to the Special Issue Extracellular Vesicles for Targeted Delivery)
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