3D Bioprinting: Current Advances and Future Directions in Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: 20 January 2026 | Viewed by 914

Special Issue Editors


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Guest Editor
Department of Biotechnology and Bioengineering, Kangwon National University, Chuncheon 24341, Republic of Korea
Interests: cancer; infectious diseases; nanoencapsulation; nanomedicine; nanoparticles; new drug delivery systems; polymersome; theragnosis
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Mechanical and Biomedical Engineering, Kangwon National University (KNU), Chuncheon 24341, Republic of Korea
Interests: 3D printing; 3D bioprinting; biomedical engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to the Special Issue titled “3D Bioprinting: Current Advances and Future Directions in Drug Delivery.” Three-dimensional bioprinting is a technology that enables fabrication of biological structures and improves drug delivery efficiency. It enhances drug accessibility, enables targeted delivery, and provides controlled drug release, addressing challenges in current pharmaceutical methods.

This Special Issue aims to present research and reviews that clarify how 3D bioprinting transforms drug delivery practices. We particularly encourage submissions bridging pharmaceutical science, clinical application, and biomaterials research. Our goal is to compile contributions that provide insight into practical implementation, methodology improvements, and translational approaches.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but not limited to) the following:

  • Innovative bioink formulations for drug delivery;
  • 3D-printed scaffolds for controlled drug release;
  • Bioprinted disease models for therapeutic screening;
  • Advances in personalized medicine via bioprinting;
  • Regulatory and translational aspects of bioprinted therapeutics.

We look forward to receiving your contributions.

Dr. Hyun-Ouk Kim
Dr. Hyungseok Lee
Guest Editors

Manuscript Submission Information

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Keywords

  • 3D bioprinting
  • drug delivery
  • bioink development
  • tissue engineering
  • controlled release systems

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Published Papers (1 paper)

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Review

26 pages, 3759 KB  
Review
3D Bioprinted Neural Tissues: Emerging Strategies for Regeneration and Disease Modeling
by Taekyung Choi, Jinseok Park, Suvin Lee, Hee-Jae Jeon, Byeong Hee Kim, Hyun-Ouk Kim and Hyungseok Lee
Pharmaceutics 2025, 17(9), 1176; https://doi.org/10.3390/pharmaceutics17091176 - 10 Sep 2025
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Abstract
Three-dimensional (3D) bioprinting has emerged as a versatile platform in regenerative medicine, capable of replicating the structural and functional intricacies of the central and peripheral nervous systems (CNS and PNS). Beyond structural repair, it enables the construction of engineered tissues that closely recapitulate [...] Read more.
Three-dimensional (3D) bioprinting has emerged as a versatile platform in regenerative medicine, capable of replicating the structural and functional intricacies of the central and peripheral nervous systems (CNS and PNS). Beyond structural repair, it enables the construction of engineered tissues that closely recapitulate neural microenvironments. This review provides a comprehensive and critical synthesis of current bioprinting strategies for neural tissue engineering, with particular emphasis on comparing natural, synthetic, and hybrid polymer-based bioinks from mechanistic and translational perspectives. Distinctively, it highlights gradient-based modulation of Schwann cell behavior and axonal pathfinding using mechanically and chemically patterned constructs. Special attention is given to printing modalities such as extrusion, inkjet, and electrohydrodynamic jet printing, examining their respective capacities for controlling spatial organization and microenvironmental cues. Representative applications include brain development models, neurodegenerative disease platforms, and glioblastoma scaffolds with integrated functional properties. Furthermore, this review identifies key translational barriers—including host tissue integration and bioink standardization—and explores emerging directions such as artificial intelligence-guided biofabrication and organ-on-chip integration, to enhance the fidelity and therapeutic potential of neural bioprinted constructs. Full article
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