Next-Generation for mRNA Vaccine Delivery
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Gene and Cell Therapy".
Deadline for manuscript submissions: 20 September 2026 | Viewed by 716
Special Issue Editor
Interests: gene therapy; modification of mRNA; targeted transfer of mRNA; translational capacity of mRNA; immunogenicity of mRNA
Special Issue Information
Dear Colleagues,
Messenger RNA (mRNA)-based therapeutics have rapidly transformed the biomedical landscape, enabling breakthroughs in vaccines, protein replacement therapies, cancer immunotherapy, and gene editing. Despite this progress, the safe, efficient, and tissue-specific delivery of mRNA remains a central challenge limiting the full therapeutic potential of these technologies. This Special Issue entitled “Next generation for mRNA vaccine delivery”, brings together cutting-edge research and perspectives that address these challenges through innovative delivery strategies and enabling technologies.
The issue highlights advances beyond first-generation lipid nanoparticles, including novel lipid architectures, polymeric and hybrid nanocarriers, biomimetic and cell-derived systems, virus-inspired platforms, and extracellular vesicle-based delivery approaches. Contributions explore strategies to improve stability, endosomal escape, targeting specificity, immune modulation, and scalability, while minimizing toxicity and off-target effects. Emphasis is also placed on delivery solutions for topical administration, e.g., oral, intranasal, and intratracheal application, as well as for systemic administration and non-injectable administration routes.
In addition, the Special Issue covers emerging concepts such as stimulus-responsive materials, programmable and modular delivery systems, and the integration of artificial intelligence and high-throughput screening for rational carrier design. Regulatory considerations, manufacturing challenges, and translational pathways are discussed to bridge the gap between laboratory innovation and clinical application.
By presenting interdisciplinary insights from materials science, nanotechnology, molecular biology, and clinical research, this Special Issue aims to define the next generation of mRNA delivery platforms and accelerate the development of safe, effective, and versatile mRNA-based therapeutics for a wide range of diseases.
Prof. Dr. Joseph Rosenecker
Guest Editor
Manuscript Submission Information
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Keywords
- gene therapy
- modification of mRNA
- targeted transfer of mRNA
- translational capacity of mRNA
- immunogenicity of mRNA
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