Exploring the Versatility of Cyclodextrins in Pharmaceutical Formulations

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 2135

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Department of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland
Interests: polymorphism; DFT calculations on molecular solids; NMR parameter calculations; molecular dynamics simulations; phase transitions
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Special Issue Information

Dear Colleagues,

The application of cyclodextrins (CDs) as pharmaceutical excipients is highly appreciated and well-established. Several papers focusing on various beneficial properties of CDs in this field have been published. CDs are commonly applied as drug delivery systems, solubilizers and absorption promoters, agents that improve drug stability, and excipients used for the heat and radiation protection of other molecules and even active pharmaceutical ingredients (APIs).

However, the applications of CDs have several drawbacks. For example, CDs are usually capable of binding only one drug molecule (fully or partially), showing poor drug loading capacity. Additionally, the relatively low stability constants of drug–CD complexes contribute to easy dissociation and release of their contents. However, due to highly reactive hydroxyl groups, CDs can act as polyfunctional monomers. The polymerization of CDs leads to the formation of cyclodextrin-based nanosponges (CDNSs) and other macromolecules.

This Special Issue aims to gather the studies in which particular attention was paid to assessing structural properties, methods of synthesis, and physicochemical analyses of CDs and CD-based materials using various analytical methods, such as DLS, PXRD, TGA, DSC, FT-IR, NMR, and phase solubility studies. Also, due to the significant role of CDs in pharmaceutical research and industry, aspects such as drug loading, drug release studies, and kinetics profile evaluations of drug–CDs complexes are within the scope of this Special Issue.

Original research papers, both experimental and theoretical, communications, and review articles are welcome for this Special Issue.

Dr. Łukasz Szeleszczuk
Guest Editor

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Keywords

  • cyclodextrins
  • CDs
  • inclusion complexes
  • cyclodextrin-based nanosponges
  • excipients
  • host–guest complexes
  • complexes

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Published Papers (1 paper)

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Review

39 pages, 5518 KiB  
Review
Cyclodextrin Inclusion Complexes with Hydrocortisone-Type Corticosteroids
by Aleksandra Kowalska and Łukasz Szeleszczuk
Pharmaceutics 2024, 16(12), 1544; https://doi.org/10.3390/pharmaceutics16121544 - 2 Dec 2024
Viewed by 1252
Abstract
The hydrocortisone-type corticosteroid (HTC) group includes valuable active pharmaceutical ingredients (APIs) such as hydrocortisone, hydrocortisone acetate, cortisone acetate, tixocortol pivalate, prednisolone, methylprednisolone, and prednisone. Unfortunately, those APIs are characterized by low solubility, which hampers their application and reduces their therapeutic efficacy. The low [...] Read more.
The hydrocortisone-type corticosteroid (HTC) group includes valuable active pharmaceutical ingredients (APIs) such as hydrocortisone, hydrocortisone acetate, cortisone acetate, tixocortol pivalate, prednisolone, methylprednisolone, and prednisone. Unfortunately, those APIs are characterized by low solubility, which hampers their application and reduces their therapeutic efficacy. The low polarity of HTC molecules allows them to form inclusion complexes with various cyclodextrins (CDs); however, as shown in this review, the type of applied CDs has a major impact on the final properties of the formed complex. HTC–CD complexes have been routinely used for over 40 years to achieve various aims. Most frequently, CDs have been utilized as HTC solubilizers and absorption enhancers in pharmaceutical formulations, as well as for separation and analysis by chromatographic and electrophoretic methods. This article reviews the studies describing the synthesis as well as the biological, physiochemical, and structural properties of the inclusion complexes formed between HTC and various cyclodextrins. Full article
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