Exploring the Versatility of Cyclodextrins in Pharmaceutical Formulations
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 2302
Special Issue Editor
Interests: polymorphism; DFT calculations on molecular solids; NMR parameter calculations; molecular dynamics simulations; phase transitions
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The application of cyclodextrins (CDs) as pharmaceutical excipients is highly appreciated and well-established. Several papers focusing on various beneficial properties of CDs in this field have been published. CDs are commonly applied as drug delivery systems, solubilizers and absorption promoters, agents that improve drug stability, and excipients used for the heat and radiation protection of other molecules and even active pharmaceutical ingredients (APIs).
However, the applications of CDs have several drawbacks. For example, CDs are usually capable of binding only one drug molecule (fully or partially), showing poor drug loading capacity. Additionally, the relatively low stability constants of drug–CD complexes contribute to easy dissociation and release of their contents. However, due to highly reactive hydroxyl groups, CDs can act as polyfunctional monomers. The polymerization of CDs leads to the formation of cyclodextrin-based nanosponges (CDNSs) and other macromolecules.
This Special Issue aims to gather the studies in which particular attention was paid to assessing structural properties, methods of synthesis, and physicochemical analyses of CDs and CD-based materials using various analytical methods, such as DLS, PXRD, TGA, DSC, FT-IR, NMR, and phase solubility studies. Also, due to the significant role of CDs in pharmaceutical research and industry, aspects such as drug loading, drug release studies, and kinetics profile evaluations of drug–CDs complexes are within the scope of this Special Issue.
Original research papers, both experimental and theoretical, communications, and review articles are welcome for this Special Issue.
Dr. Łukasz Szeleszczuk
Guest Editor
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Keywords
- cyclodextrins
- CDs
- inclusion complexes
- cyclodextrin-based nanosponges
- excipients
- host–guest complexes
- complexes
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