Novel Lymphatic Drug Delivery Systems
A Special Issue of Pharmaceutics (ISSN 1999-4923) belonging to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: 30 April 2027 | Viewed by 80
Editors
Interests: lymphatic drug delivery systems; intranodal therapy; lymph node metastasis; cancer immunotherapy; experimental pathology; lymphatic biology
Interests: lymphatic drug delivery systems; biomedical engineering; lymph node metastasis; cancer therapy; lymphatic pharmacokinetics; clinical translation
Special Issue Information
Dear Colleagues,
The lymphatic system is increasingly recognized as both a therapeutic target and a transport pathway that can improve regional drug exposure while limiting systemic toxicity. Advances in formulation science, nanomedicine, imaging, and lymphatic biology now enable more precise delivery to lymphatic vessels, lymph nodes, and lymph-associated disease sites. However, clinical translation remains constrained by incomplete understanding of lymphatic uptake, intranodal distribution, retention, lymph-to-blood transport, formulation-dependent pharmacokinetics, and safety.
This Special Issue aims to integrate mechanistic, technological, preclinical, and clinical advances in lymphatic drug delivery within the scope of Pharmaceutics. We welcome submissions addressing oral, subcutaneous, intradermal, intralymphatic, and intranodal delivery; lymph node-targeted formulations, nanoparticles, biologics, nucleic acids, vaccines, and immunotherapies; physicochemical determinants of lymphatic uptake, distribution, and retention; imaging, modeling, and quantitative pharmacokinetics; and anatomical or biological barriers relevant to lymphatic transport. Applications in cancer, infection, and inflammatory or immune-mediated diseases are particularly encouraged, together with studies on safety, manufacturing, regulatory considerations, and clinical translation. By connecting pharmaceutics with lymphatic biology, biomedical engineering, and therapeutic development, this collection seeks to establish practical design principles and accelerate the development of precise, effective, and clinically translatable lymphatic therapeutics.
Dr. Ariunbuyan Sukhbaatar
Dr. Tetsuya Kodama
Guest Editors
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Keywords
- lymphatic drug delivery
- lymph node targeting
- lymphatic transport
- intranodal administration
- nanomedicine
- drug formulation
- pharmacokinetics
- cancer immunotherapy
- lymphatic imaging
- clinical translation
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