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Pharmaceutics
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Development of Skin Barrier Repair Therapy Formulations for Skin Care...
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Development of Skin Barrier Repair Therapy Formulations for Skin Care Purposes

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 585

Special Issue Editors

Dr. Jiun-Wen Guo

E-Mail Website
Guest Editor
Department of Medical Research, Cathay General Hospital, Taipei 10630, Taiwan
Interests: skin barrier; inflammatory skin; topical delivery
Dr. Irene Clemes Külkamp-Guerreiro

E-Mail Website
Guest Editor
Departamento de Produção de Matéria-Prima, Unviersidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, RS, Brazil
Interests: nanotechnology; pharmaceutical technology, skin; cosmetics; pediatric products
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Skin barrier dysfunction is a crucial factor in the pathogenesis of various dermatological conditions, including atopic dermatitis, psoriasis, ichthyosis, and contact dermatitis. Traditional treatment strategies, such as emollients and moisturizers, are widely used to alleviate symptoms, yet they often fail to address the underlying biochemical abnormalities in the stratum corneum. Recent advancements in barrier repair therapy (BRT), particularly physiological lipid-based formulations, have demonstrated promising results in restoring skin homeostasis by incorporating optimized ratios of ceramides, cholesterol, and free fatty acids.

This Special Issue aims to highlight recent innovations in skin barrier repair formulations, including novel lipid-based delivery systems, biomimetic formulations, and targeted therapeutic approaches for improving barrier integrity and reducing inflammatory responses. We welcome the submission of original research and review articles focusing on formulation design, mechanism studies, clinical applications, and emerging technologies in skin barrier repair therapies. We look forward to receiving your contributions.

Dr. Jiun-Wen Guo
Dr. Irene Clemes Külkamp-Guerreiro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin barrier repair therapy
  • physiological lipid-based formulations
  • dermatological formulation development
  • stratum corneum homeostasis
  • novel delivery systems in skincare

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Published Papers (1 paper)

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Research

26 pages, 2613 KiB  
Article
Sustainable Olive Pomace Extracts for Skin Barrier Support
by Roberta Cougo Riéffel, Lucas Agostini, Naira Poener Rodrigues, Simone Jacobus Berlitz, Lígia Damasceno Ferreira Marczak and Irene Clemes Külkamp-Guerreiro
Pharmaceutics 2025, 17(8), 962; https://doi.org/10.3390/pharmaceutics17080962 - 25 Jul 2025
Viewed by 365
Abstract
Background: Olive pomace, a byproduct of olive oil production, represents approximately 85% of the processed material and poses environmental risks when improperly discarded. Its composition is rich in polyphenols with potential for cosmetic use, especially in skin barrier care. Objective: To [...] Read more.
Background: Olive pomace, a byproduct of olive oil production, represents approximately 85% of the processed material and poses environmental risks when improperly discarded. Its composition is rich in polyphenols with potential for cosmetic use, especially in skin barrier care. Objective: To develop a natural extract rich in antioxidants from olive pomace using sustainable solvents (water and 1,3-propanediol) for skin barrier support. Methods: The phenolic composition and in vitro biological activities of the extracts were analyzed. Results: The extracts demonstrated a reducing capacity (15 to 33 mg GAE/g) and flavonoid content (4 to 5 mg QE/g). In addition, their antioxidant capacity was proven through the inhibition of the DPPH radical (7% to 91%) and ABTS (7% to 95%) and the reduction in oxidation in the beta-carotene/linoleic acid system (6% to 35%), presenting results superior to those of tocopherol acetate. The hydroxytyrosol and oleuropein compounds, ranging from 28 to 54 and 51 to 85 µg/mL, respectively, were quantified via HPLC. The extract with the highest levels of hydroxytyrosol and oleuropein was analyzed via UHPLC-QqTOF-MS, and 33 compounds were identified. This extract showed antiglycation activity (24% to 40%). The incorporation of this extract into a cosmetic emulsion resulted in sufficient antioxidant capacity to replace tocopherol acetate. Conclusions: The use of effective extraction techniques and nontoxic solvents ensures the sustainability and safety of the extract for application as a natural cosmetic ingredient, aiming to promote the health and integrity of the skin barrier. Full article
(This article belongs to the Special Issue Development of Skin Barrier Repair Therapy Formulations for Skin Care Purposes)
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