Targeted Biomolecule Delivery via Extracellular Vesicles in Inter-Organ Cross-Talk and Neuroinflammation
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biologics and Biosimilars".
Deadline for manuscript submissions: 20 August 2025 | Viewed by 52
Special Issue Editors
Interests: extracellular vesicles; differentiation; neuroinflammation; apoptosis; autophagy; cancer therapy; neurodegenerative diseases; inflammatory disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Bidirectional communication networks between the brain and other organs, such as the heart, adipose tissue, liver, and gut, are emerging, with extracellular vesicles (EVs) playing a significant role int the dissemination of inflammatory signals between organs. In addition, the use of EVs to perform targeted biomolecule delivery, facilitate inter-organ communication and address neuroinflammation is an emerging and appealing field of research. Several studies have highlighted the dual role of EVs in promoting both neuroprotection and neurodegeneration, depending on their origin and cargo composition.
This Special Issue explores the pivotal role of EVs in mediating inter-organ communication in several neurodegenerative and inflammatory disorders, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and multiple sclerosis. As key players in cell-to-cell communication, EVs are implicated in various physiological and pathological conditions as they facilitate the exchange of bioactive molecules between the nervous system and other organs and propagate inflammatory signals; in turn, these signals modulate systemic inflammation and influence the progression of disease. Therefore, this Special Issue aims to highlight innovative strategies that utilize EVs as vehicles for targeted therapeutics, emphasizing their potential to modulate inflammatory responses in the nervous system.
In summary, this Special Issue underscores the significance of EVs in orchestrating complex inter-organ interactions during neuroinflammatory responses by delivering bioactive molecules. Moreover, contributions in this collection address a range of topics, including the characterization of EVs derived from various cell types, mechanisms of cargo loading, and methods for enhancing the specificity and efficacy of EV-mediated delivery.
Furthermore, this Special Issue addresses the challenges and future directions in EV-mediated delivery, highlighting the need for standardized protocols that enhance the isolation and characterization of EVs. This is crucial for enhancing the specificity and efficacy of their therapeutic applications. Additionally, the need to translate EV-based therapies into clinical practice is emphasized, as it is key to realizing their full potential. By compiling innovative research articles and reviews, this Special Issue aims to inspire further research on the mechanisms and optimization of EV-mediated delivery. This will aid in modulating inter-organ communication and alleviating neuroinflammation, ultimately paving the way for innovative treatment strategies in neurodegenerative and inflammatory disorders.
Dr. Elisa Panzarini
Dr. Elisabetta Carata
Guest Editors
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Keywords
- extracellular vesicles
- targeted biomolecules delivery
- brain-gut axis
- brain-muscle communication
- periphery-brain crosstalk
- bilateral communication
- central nervous system disorders
- neuroinflammation
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