Exploring Solid Dosage Forms: Characterization, Dissolution, and Stability

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 30 May 2025 | Viewed by 433

Special Issue Editor


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Guest Editor
Faculty of Pharmaceutical Sciences, Federal University of Alfenas (UNIFAL-MG), Alfenas 37130-001, MG, Brazil
Interests: solid dosage forms; crystal; drug dissolution; drug stability

Special Issue Information

Dear Colleagues,

Solid dosage forms, such as tablets and capsules, represent a cornerstone of pharmaceutical formulations, playing a critical role in drug delivery systems. These forms significantly influence drug release kinetics, bioavailability, absorption, and overall therapeutic efficacy. The characterization of solid dosage forms involves a comprehensive analysis of their physicochemical properties, including solubility, stability, and solid-state characteristics, which are essential for ensuring optimal performance in vivo. Recent advancements in analytical methodologies for assessing dissolution profiles, intrinsic dissolution rates, and solid-state transitions have proven pivotal in elucidating the pharmacokinetics of active pharmaceutical ingredients (APIs). Moreover, the interplay between formulation variables and environmental conditions, as exemplified by studies on phase transitions and solubility behaviors of various crystalline forms, highlights the complexity of solid dosage forms.

This Special Issue aims to compile high-quality research articles and reviews that explore the characterization, dissolution, and stability of solid dosage forms, addressing both fundamental principles and applied methodologies in the field. We invite researchers to contribute their findings and insights into this critical field of study, enhancing our collective understanding of solid dosage forms.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Phase transitions and solubility studies of various crystalline forms;
  • Quality evaluation of water samples used in pharmaceutical compounding;
  • Application of multivariate optimization strategies in analytical method validation;
  • Solid-state characterization and stability assessments of novel compounds;
  • Dissolution studies emphasizing the discriminatory power of assays for various drug formulations;
  • Comprehensive reviews on analytical methods for quantification of drugs in solid dosage forms.

I look forward to receiving your contributions that will enrich this Special Issue and advance our understanding of solid dosage forms in pharmaceutical sciences.

Prof. Dr. Magali B. Araújo
Guest Editor

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Keywords

  • solid dosage forms
  • drug release kinetics
  • physicochemical properties
  • dissolution testing
  • stability assessment
  • crystalline forms
  • pharmaceutical formulations
  • analytical methods

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Published Papers (1 paper)

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18 pages, 2736 KiB  
Article
Intrinsic Dissolution Modeling: Interdependence Between Dissolution Rate, Solubility, and Boundary Layer Thickness
by Amelie Marie Mattusch, Gerhard Schaldach, Jens Bartsch and Markus Thommes
Pharmaceutics 2025, 17(5), 570; https://doi.org/10.3390/pharmaceutics17050570 - 25 Apr 2025
Viewed by 166
Abstract
Background/Objectives: In the past, many drug release models have been presented which attempt to describe the interaction of drugs and excipients in a formulation. Nevertheless, modeling the intrinsic dissolution behavior is essential for understanding the fundamental dissolution mechanisms of drugs and for [...] Read more.
Background/Objectives: In the past, many drug release models have been presented which attempt to describe the interaction of drugs and excipients in a formulation. Nevertheless, modeling the intrinsic dissolution behavior is essential for understanding the fundamental dissolution mechanisms of drugs and for enhancing the quality of computational approaches in the long term. Methods: In this study, the intrinsic dissolution of various pharmaceutical model substances (benzocaine, carbamazepine, griseofulvin, ibuprofen, naproxen, phenytoin, theophylline monohydrate, and trimethoprim) was investigated in dissolution experiments, taking into account the flow conditions in a dissolution channel apparatus. A practicable and generally valid representation was identified to describe the diffusion properties of the drugs in terms of the boundary layer thickness without considering the particle size distribution, physical state, or viscoelastic properties. This representation was supported by numerical simulations using a high-resolution mesh. The influence of the topography on the modeling was also examined. Results: Besides the prediction of the influence of a surface reaction limitation or the solubility of a diffusion controlled drug, the boundary layer thickness at the tablet surface is modellable in terms of a freely selectable length and as a function of the diffusion coefficient, drug solubility, and the flow velocity of the dissolution medium. Conclusions: Using different methods and a large dataset, this study presents a modeling approach that can contribute to a deeper understanding of intrinsic dissolution behavior. Full article
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