Synaptic Dysfunction in Neurological Diseases
A special issue of Pharmaceuticals (ISSN 1424-8247).
Deadline for manuscript submissions: closed (28 February 2021)
Special Issue Editor
2. Ann Romney Center of Neurologic Diseases, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, USA
Interests: microRNAs; non-coding RNAs; brain disorders; Alzheimer’s disease; brain tumors; RNA-based therapeutic
Special Issue Information
Dear Colleagues,
We are pleased to announce a Special Issue in the topic of “Synaptic Dysfunction in Neurological Diseases” in Pharmaceuticals journal. The complexity of brain functions is linked to the accelerated evolution of synapses, especially in primates. Synapses can operate with a certain degree of autonomy from the cell body, and their outstanding complexity results in a great variety of possible synaptic alterations. Synaptic dysfunction can result either from alterations in their intrinsic synaptic molecular mechanisms, or be secondary to changes in additional biochemical processes in the surrounding environment. Many psychiatric and neurologic disorders, including mental retardation, autism, Parkinson, Alzheimer's diseases, and addiction, are accompanied by alterations in spine morphology, synapse number, signaling dysfunction, and/or changes in localized translation. The relationship between synaptic signaling, spine shape, brain function, and local translation at the synapse is never more apparent than when the brain becomes dysfunctional. In this vision, this Special Issue aims to decipher all research on aberrant synapse physiology, by describing how dysregulation in synapse biology contributes to the pathogenesis of neurological diseases, and may directly contribute to neurodevelopmental disorders and neurodegenerative disorders, as well as psychiatric diseases.
Dr. Rachid El Fatimy
Guest Editor
Manuscript Submission Information
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Keywords
- Synaptic dysfunction—synapthopaties
- Local translation at the synapses in neurological diseases
- Synapse structures in neurological diseases
- Synaptic transmission in neurological diseases
- Synaptic signaling in neurological diseases
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