Cardiovascular Physiology and Haemodynamics: Haemodynamic Optimisation

A special issue of Pathophysiology (ISSN 1873-149X).

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1449

Special Issue Editors


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Guest Editor
Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Interests: oxidative stress; cardiology; pharmacology; diabetes; apoptosis; internal medicine; hypertension; antioxidants; reactive oxygen species; rehabilitation

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Guest Editor
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Interests: oxidative stress; cardiovascular pharmacology; diabetes; apoptosis; pharmaceutical chemistry; hypertension; antioxidants; reactive oxygen species

Special Issue Information

Dear Colleagues,

It is our great pleasure to present you this Special Issue aimed at providing a comprehensive overview of the latest research achievements, challenges, and recommendations concerning haemodynamic optimisation. As you all know, haemodynamic optimisation includes a series of therapeutic interventions on the cardiovascular system in order to provide an optimal oxygen supply in critical conditions, such as high-risk surgery. Over the past two decades, interest in the concept of pre-, peri-, and post-operative haemodynamic optimisation has grown as a result of the evidence that demonstrate the advantages for patient outcomes. However, there are still a bulk of discordant findings and arising questions which impose the need for a deeper understanding of the underlying mechanisms and factors that influence the success of maintaining cardiovascular function. The papers resulting from this Special Issue will therefore make an important contribution to the understanding of this procedure, whose usefulness in a practical work seems justified. Therefore, original articles based on animal and human investigations, as well as systematic reviews, are more than welcome in this Special Issue. Potential topics include, but are not limited to, the following research areas:

  • Myocardial ischemia/reperfusion injury;
  • Oxidative stress in cardiovascular diseases;
  • Endothelial dysfunction;
  • Operative care;
  • Fluid replacement.

We look forward to your contributions.

Prof. Dr. Vladimir Jakovljevic
Dr. Nevena Jeremic
Guest Editors

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Keywords

  • cardiovascular system
  • haemodynamics
  • fluids
  • operative care
  • oxygen supply

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Published Papers (1 paper)

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Research

19 pages, 1819 KiB  
Article
Diagnostic Utility of N-Terminal Pro-B-Type Natriuretic Peptide in Identifying Atrial Fibrillation Post-Cryptogenic Stroke: A Systematic Review and Meta-Analysis
by Jay Patel and Sonu M. M. Bhaskar
Pathophysiology 2024, 31(3), 331-349; https://doi.org/10.3390/pathophysiology31030024 - 30 Jun 2024
Viewed by 1017
Abstract
Background: Atrial fibrillation (AF) significantly contributes to acute ischemic stroke, with undetected AF being a common culprit in cryptogenic strokes. N-terminal pro-B-type natriuretic peptide (NT-proBNP), indicative of myocardial stress, has been proposed as a biomarker for AF detection, aiding in the selection of [...] Read more.
Background: Atrial fibrillation (AF) significantly contributes to acute ischemic stroke, with undetected AF being a common culprit in cryptogenic strokes. N-terminal pro-B-type natriuretic peptide (NT-proBNP), indicative of myocardial stress, has been proposed as a biomarker for AF detection, aiding in the selection of patients for extended cardiac monitoring. However, the diagnostic accuracy of NT-proBNP remains uncertain. Methods: We conducted a meta-analysis to evaluate the diagnostic accuracy of NT-proBNP in detecting AF among cryptogenic stroke patients. A comprehensive literature search was conducted across PubMed, Embase, and Cochrane databases to identify relevant studies. Studies reporting NT-proBNP levels in stroke patients and data on the proportion of patients with AF above a specified cut-off were included. Meta-analyses were performed using the midas command in STATA. Results: Seven studies encompassing 2171 patients were included in the analysis, of which five studies contained cohorts with cryptogenic strokes. Among patients with cryptogenic stroke, NT-proBNP demonstrated a diagnostic accuracy of 80% (Area Under the Receiver Operating Curve 0.80 [95% CI 0.76–0.83]), with a sensitivity of 81% (95% CI 0.68–0.89) and a specificity of 68% (95% CI 0.60–0.75). Conclusion: Our meta-analysis indicates that NT-proBNP exhibits a good-to-very-good diagnostic accuracy for detecting AF in patients with cryptogenic stroke. These findings suggest potential implications for utilizing NT-proBNP in guiding the selection of patients for prolonged cardiac monitoring, thereby aiding in the management of cryptogenic stroke cases. Full article
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