New Advances in Epidemiology of Neglected Tropical Diseases

A special issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: 15 April 2026 | Viewed by 910

Special Issue Editors


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Guest Editor
1. Jiangsu Provincial Medical Innovation Center, National Health Commission Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Center for Disease Control and Prevention (Jiangsu Provincial Academy of Preventive Medicine), Nanjing, China
2. School of Public Health, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, China
3. School of Public Health, Southeast University, Nanjing, China
Interests: vaccine clinical trials; vaccine development; vaccine immunization; epidemiology of infectious diseases

Special Issue Information

Dear Colleagues,

Neglected tropical diseases are a group of diseases that affect over one billion people worldwide and cause illness, disability, and mortality. To accelerate the progress towards global elimination, the World Health Organization launched “Ending the neglect to attain the Sustainable Development Goals: a road map for neglected tropical diseases 2021–2030” in early 2021. However, this roadmap was greatly hindered by the global COVID-19 pandemic, and there are currently still multiple challenges to the global elimination/eradication of neglected tropical diseases, despite the great strides achieved. Recently, a diverse variety of novel tools were introduced into the management of neglected tropical diseases, including artificial intelligence, nucleic acid tests, and next-generation sequencing. In addition, the One Health concept is widely accepted as a multidisciplinary approach to tacking the challenge of neglected tropical diseases. This Special Issue aims to publish research and review articles presenting advances in the epidemiology of neglected tropical diseases.

Prof. Dr. Wei Wang
Prof. Dr. Jingxin Li
Prof. Dr. Jian Li
Guest Editors

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Keywords

  • neglected tropical diseases
  • molecular epidemiology
  • artificial intelligence
  • nucleic acid test
  • One Health

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Published Papers (1 paper)

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Research

12 pages, 2066 KB  
Article
Burden of Soil-Transmitted Helminth Infections in China: Historical Trends (1990–2021) and Future Projections (2035)
by Bixian Ni, Yanzheng Zou, Luqiu Tao and Wei Wang
Pathogens 2025, 14(11), 1114; https://doi.org/10.3390/pathogens14111114 - 2 Nov 2025
Viewed by 497
Abstract
Background: Soil-transmitted helminth (STH) infections, including ascariasis, trichuriasis, and hookworm disease, are among the most common neglected tropical diseases (NTDs) globally. This study evaluates the disease burden of STH in China from 1990 to 2021 and projects trends to 2035. Methods: Data from [...] Read more.
Background: Soil-transmitted helminth (STH) infections, including ascariasis, trichuriasis, and hookworm disease, are among the most common neglected tropical diseases (NTDs) globally. This study evaluates the disease burden of STH in China from 1990 to 2021 and projects trends to 2035. Methods: Data from the Global Burden of Disease 2021 database were utilized to analyze the prevalence and disability-adjusted life years (DALYs) of STH infections in China from 1990 to 2021. The estimated annual percentage change (EAPC) was calculated to assess trends over time, and a Bayesian age-period-cohort model was used to project the disease burden up to 2035. Results: From 1990 to 2021, the prevalence and DALYs of STH infections decreased significantly by 85.08% and 98.01% in China, respectively. The age-standardized prevalence rate (ASPR) of STH infections dropped from 34,073.24/105 to 4981.01/105 with an EAPC of −6.62% [95% confidence interval (CI): −7.40%, −5.83%], and the age-standardized DALY rate (ASDR) decreased from 1.77/105 to 0.18/105, with an EAPC of −14.05% (95% CI: −15.04%, −13.06%). Trichuriasis contributed to 78.85% of the total ASPR for STH, whereas hookworm disease accounted for 51.14% of STH’s ASDR. The highest disease burden due to STH peaked in the 5–9 years age group, with prevalence of 8030.05/105 [95% uncertainty interval (UI): 5356.86/105–11,662.62/105] and DALYs rate of 2.99/105 (95% UI: 1.56/105−4.87/105). The projected ASDR and ASPR of trichuriasis rose to 0.55/105 and 5362.50/105 by 2035. Conclusions: China has achieved remarkable reductions in the burden of STH infections over the past three decades. However, the predominance between the species has changed. The projected rebound in trichuriasis underscores the importance of sustained control efforts. To achieve the 2030 elimination target outlined in the WHO NTDs roadmap, it is crucial to integrate precision epidemiology with ongoing water, sanitation, and hygiene initiatives, targeted chemotherapy and health education. Full article
(This article belongs to the Special Issue New Advances in Epidemiology of Neglected Tropical Diseases)
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