Exploring the Epidemiology, Pathogenicity, and Therapeutic Options of Staphylococcus spp.: 2nd Edition

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 836

Special Issue Editors

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Guest Editor
Department of Veterinary Medicine and Animal Production, University of Naples “Federico II”, Via F. Delpino 1, 80137 Naples, Italy
Interests: veterinary bacteriology; bacterial infections in domestic animals; Staphylococcus pseudintermedius infections; antimicrobial susceptibility testing; antimicrobial resistance genes
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Guest Editor
Department of Veterinary Sciences, University of Turin, Largo P. Braccini 2, 10095 Grugliasco, Italy
Interests: clinical bacteria; antibiotic-resistance; veterinary bacterial diseases
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Special Issue Information

Dear Colleagues,

Staphylococci are the main inhabitants of skin and mucosa of both animals and humans, in which these opportunistic Gram-positive bacteria can be responsible for a great variety of infections, including pyoderma, otitis, abscesses, mastitis, urinary tract infections, and wound infections. 

Over the last decade, both coagulase-positive Staphylococci (CoPS) and coagulase-negative Staphylococci (CoNS) have become critically opportunistic animal pathogens, frequently being the primary etiological agents of infections such as otitis and pyoderma in small animals. Furthermore, the potential zoonotic transmission of these pathogens should not be underestimated, with animals acting as reservoirs for humans.

The recent emergence and rapid dissemination of multidrug-resistant staphylococcal strains, particularly methicillin-resistant S. aureus and S. pseudintermedius, showing increasingly frequent resistance to the antibiotic agents licensed for use in small and farm animal practice, represent a relevant threat to animal and public health. In the last decade, the antibiotic resistance issue has become increasingly relevant, underlining the need of a continuous surveillance of both methicillin-resistant and methicillin-susceptible Staphylococci, as well as the development of new and alternative therapeutic options. 

This Special Issue aims at establishing a collection of papers exploring the occurrence of Staphylococcus spp. in small animals, livestock, wildlife, and humans, the pathogenic mechanisms involved in the onset of the infection, the mechanisms of antibiotic resistance, the diagnostic tools, and the new alternative treatment approaches to prevent and limit the dissemination of multidrug-resistant strains. 

We look forward to receiving research articles, review articles, and short communications on these topics that warrant further exploration.

Dr. Francesca Paola Nocera
Prof. Dr. Patrizia Nebbia
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Staphylococcus spp.
  • transmission
  • pathogenesis of infections
  • antibiotic resistance
  • methicillin resistance
  • therapy
  • zoonotic diseases
  • One Health

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Published Papers (1 paper)

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12 pages, 1242 KiB  
Staphylococcus hsinchuensis sp. nov., Isolated from Soymilk
by Yu-Ting Wang, Yu-Chun Lin, Yi-Huei Hsieh, Yu-Tzu Lin, Moriyuki Hamada, Chih-Chieh Chen, Jong-Shian Liou, Ai-Yun Lee, Wei-Ling Zhang, Yung-Tsung Chen and Chien-Hsun Huang
Pathogens 2024, 13(4), 343; https://doi.org/10.3390/pathogens13040343 - 21 Apr 2024
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A novel coagulase-negative Staphylococcus strain (H164T) was isolated from soymilk in Taiwan. Comparative sequence analysis of the 16S rRNA gene revealed that the H164T strain is a member of the genus Staphylococcus. We used multilocus sequence analysis (MLSA) and [...] Read more.
A novel coagulase-negative Staphylococcus strain (H164T) was isolated from soymilk in Taiwan. Comparative sequence analysis of the 16S rRNA gene revealed that the H164T strain is a member of the genus Staphylococcus. We used multilocus sequence analysis (MLSA) and phylogenomic analyses to demonstrate that the novel strain was closely related to Staphylococcus gallinarum, Staphylococcus nepalensis, Staphylococcus cohnii, and Staphylococcus urealyuticus. The average nucleotide identity and digital DNA-DNA hybridization values between H164T and its closest relatives were <95% and <70%, respectively. The H164T strain could also be distinguished from its closest relatives by the fermentation of d-fructose, d-maltose, d-trehalose, and d-mannitol, as well as by the activities of α-glucosidase and alkaline phosphatase. The major cellular fatty acids were C15:0 iso and C15:0 anteiso, and the predominant menaquinones were MK-7 and MK-8, respectively. The major cellular fatty acids and predominant menaquinones were C15:0 iso and C15:0 anteiso and MK-7 and MK-8, respectively. In conclusion, this strain represents a novel species, named Staphylococcus hsinchuensis sp. nov., with the type strain H164T (=BCRC 81404T = NBRC 116174T). Full article
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