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Mycobacterium tuberculosis Pathogenesis, Infection Prevention and Treatment
Open AccessArticle

Interleukin-18, Functional IL-18 Receptor and IL-18 Binding Protein Expression in Active and Latent Tuberculosis

1
Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland
2
Regional Specialized Hospital of Tuberculosis, Lung Diseases, and Rehabilitation, Szpitalna 5, 95-080 Tuszyn, Poland
3
Center for Medical Genomics OMICRON, Jagiellonian University, Medical College, Swietej Anny 12, 31-008 Cracow, Poland
*
Author to whom correspondence should be addressed.
Pathogens 2020, 9(6), 451; https://doi.org/10.3390/pathogens9060451
Received: 30 April 2020 / Revised: 30 May 2020 / Accepted: 4 June 2020 / Published: 8 June 2020
A thorough understanding of the processes modulating the innate and acquired immune response to Mycobacterium tuberculosis (M.tb) infection in the context of gene expression is still a scientific and diagnostic problem. The study was aimed to assess IL-18, IL-18 binding protein (IL-18BP), IL-18R, IFN-γ, and IL-37 mRNA expression in patients with active tuberculosis (ATB) and healthy volunteers with latent M.tb-infection (LTB) or M.tb-uninfected healthy controls (Control). The relative mRNA expression was assessed in the buffy coat blood fraction using the qPCR method. In total, 97 BCG-vaccinated Polish adults were enrolled in the study. The relative expression of IL-18 and IL-18BP mRNA was significantly elevated in the ATB and LTB groups. In ATB, but not LTB individuals, the overexpression of IL-18 and IL-18BP, as well as a significant increase in IFN-γ mRNA expression, might be considered as a manifestation of active tuberculosis disease. No statistically significant differences were observed in the IL-37 mRNA expression among the studied groups. Particularly noteworthy is the outstanding reduction in the relative expression of IL-18R mRNA in the LTB group as compared to the ATB and Control group. Reduced expression of IL-18R in LTB group may, at least partially, prevent the development of a pathological inflammatory reaction and promote the maintenance of homeostatic conditions between host immunity and M.tb. View Full-Text
Keywords: tuberculosis; IL-18; IL-18BP; IL-18R; gene expression tuberculosis; IL-18; IL-18BP; IL-18R; gene expression
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Wawrocki, S.; Kielnierowski, G.; Rudnicka, W.; Seweryn, M.; Druszczynska, M. Interleukin-18, Functional IL-18 Receptor and IL-18 Binding Protein Expression in Active and Latent Tuberculosis. Pathogens 2020, 9, 451.

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