Special Issue "Hantavirus Infections"

A special issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: 31 May 2020.

Special Issue Editor

Dr. Tarja Sironen
Guest Editor
University Researcher at Viral Zoonosis Research unit, University of Helsinki, Helsinki, Finland
Interests: Genetics; Evolution; Phylogenetic Analysis; Phylogenetics; Virus; Molecular Clocks; Hantavirus; Bunyaviridae; Hantavirus Infections; Rodent-borne Viruses; Bat-borne Viruses; Virus-host Interaction; One Health; Disease Ecology

Special Issue Information

Dear Colleagues,

Hantaviruses (genus Orthohantavirus) are zoonotic pathogens that cause in humans disease with severity ranging from subclinical to fatal. In contrast, the infection in the reservoir host is thought to be asymptomatic and persistent. Rodents were considered the main hosts of hantaviruses, but the reservoir host range has expanded to mammalian species of the orders Eulipotyphla and Chiroptera. In addition, the catalogue of hantavirus species is increasing, as is the notified global distribution of hantavirus infections. Surveillance data is needed to assess the current disease burden of hantavirus infections and diagnostic tests need to be updated to detect all hantavirus pathogens. Research on the factors affecting hantavirus transmission and maintenance in the different reservoir hosts, and spillover to humans are urgently needed to plan intervention strategies and predict changes due to environmental change. This Special Issue values updates on the epidemiology of hantavirus infections and assessment of pathogenicity of the newly detected hantaviruses. Reports on all aspects of hantavirus biology are welcome.

Dr. Tarja Sironen
Guest Editor

Manuscript Submission Information

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  • hantavirus
  • hemorrhagic fever with renal syndrome
  • hantavirus (cardio)pulmonary syndrome
  • reservoir host
  • rodent-borne virus
  • zoonoses
  • epidemiology
  • virus evolution
  • pathogenesis
  • disease ecology

Published Papers (1 paper)

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Open AccessReview
Ecology of Neglected Rodent-Borne American Orthohantaviruses
Pathogens 2020, 9(5), 325; https://doi.org/10.3390/pathogens9050325 - 26 Apr 2020
The number of documented American orthohantaviruses has increased significantly over recent decades, but most fundamental research has remained focused on just two of them: Andes virus (ANDV) and Sin Nombre virus (SNV). The majority of American orthohantaviruses are known to cause disease in [...] Read more.
The number of documented American orthohantaviruses has increased significantly over recent decades, but most fundamental research has remained focused on just two of them: Andes virus (ANDV) and Sin Nombre virus (SNV). The majority of American orthohantaviruses are known to cause disease in humans, and most of these pathogenic strains were not described prior to human cases, indicating the importance of understanding all members of the virus clade. In this review, we summarize information on the ecology of under-studied rodent-borne American orthohantaviruses to form general conclusions and highlight important gaps in knowledge. Information regarding the presence and genetic diversity of many orthohantaviruses throughout the distributional range of their hosts is minimal and would significantly benefit from virus isolations to indicate a reservoir role. Additionally, few studies have investigated the mechanisms underlying transmission routes and factors affecting the environmental persistence of orthohantaviruses, limiting our understanding of factors driving prevalence fluctuations. As landscapes continue to change, host ranges and human exposure to orthohantaviruses likely will as well. Research on the ecology of neglected orthohantaviruses is necessary for understanding both current and future threats to human health. Full article
(This article belongs to the Special Issue Hantavirus Infections)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Rat-transmitted Seoul orthohantavirus disease: forgotten, or still underestimated

By Jan Clement, Piet Maes, Marc Van Ranst, Jean-Marc Reynes


Flash-like albuminuria in acute kidney injury caused by Puumala hantavirus infection

By Paula Mantula1*, Johanna Tietäväinen1,2, Jan Clement3, Onni Niemelä2,4, Ilkka Pörsti1,2, Antti Vaheri5, Jukka Mustonen1,2, Satu Mäkelä1,2, Tuula Outinen1

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