Viral Hepatitis and Therapeutic Strategies

A special issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: 20 November 2025 | Viewed by 9

Special Issue Editor


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Guest Editor
Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA
Interests: hepatic disorders; chronic hepatitis; chronic liver failure; liver cirrhosis

Special Issue Information

Dear Colleagues,

Viral hepatitis is a major cause of liver disease worldwide. Numerous different strains of viruses can cause hepatitis, including hepatitis A, B, C, D, and E, where hepatitis A-C are the most common infections, while hepatitis D and E occur less frequently. The duration, severity, and treatment options for viral hepatitis particularly depend on the type of pathogen and associated comorbidities. Some individuals may promptly develop fulminant liver failure requiring urgent liver transplantation, while others slowly progress towards end-stage liver disease, including cirrhosis and hepatocellular carcinoma. Regardless of the significant advancement in the understanding of these infections, the mechanism of pathogenesis remains a complicated and scarcely defined process mediated by complex interactions between the host and the virus, making it difficult to achieve a functional cure. The comprehensive understanding of the host–pathogen interaction dynamics on molecular and cellular levels, the mechanisms of viral entry into the hepatocytes and their replication process, the evasion of the host immune response, and the initiation of hepatocellular damage and its subsequent progression towards end-stage liver disease is really warranted to develop novel and more effective therapeutic strategies to treat every individual, as the current approved treatment modalities show limited efficacy in complete and successful viral eradication. Hence, there is a critical need for newer molecules to achieve a functional cure.

Dr. Arshi Khanam
Guest Editor

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Keywords

  • viral hepatitis
  • acute and chronic infections
  • viral pathogenesis and persistence
  • therapeutic strategies

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Published Papers

This special issue is now open for submission.
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