Post-translational Modifications, a Powerful Mechanism for Bacterial Life and Survival

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 1677

Special Issue Editors


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Guest Editor
Laboratoire Polymères, Biopolymères, Surfaces (PBS), UMR 6270 CNRS, Université de Rouen, 76821 Mont-Saint-Aignan Cedex, France
Interests: post-translational modifications; bacteria; proteomics; mass spectrometry; lysine acylation
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Guest Editor
Laboratoire Polymères, Biopolymères, Surfaces, UMR 6270 CNRS, Université Rouen Normandie, Rouen, France
Interests: post-translational modifications; proteomics; systems biology; bioinformatics; machine learning

Special Issue Information

Dear Colleagues,

Post-translational modifications are key molecular events occurring in bacteria. Bacteria use them to respond rapidly and efficiently to external stresses and to survive in hostile environments. PTMs (phosphorylations, acetylations, glycosylations, etc.) and the enzymes involved in the protein modification mechanism have been shown to play an important role in virulence, biofilm formation, and antibiotic resistance. New PTMs are discovered regularly and their study is necessary to understand their role in bacterial physiology.

In this Pathogens Special Issue, we invite the submission of research articles or reviews that deal with the impact of bacterial co- and post-translational modifications on virulence, resistance, biofilm formation, stress response, or even host interaction. Advances and innovations in the methodologies used to study these PTMs are also of interest in this Special Issue (proteomics, bioinformatics, etc.). This Special Issue will be an opportunity to bring together the latest innovations and research in the field of bacterial PTMs. The participants of the 5th International Congress on Bacterial TMPs are especially encouraged to submit articles presenting their novel research. Articles from laboratories working on this topic that did not attend the congress will also be welcome.

Dr. Julie Hardouin
Dr. Nicolas Nalpas
Guest Editors

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Keywords

  • post-translational modifications
  • bacteria
  • proteomics
  • virulence
  • resistance
  • biofilm
  • host interaction
  • stress response
  • bioinformatics

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Published Papers (1 paper)

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Research

14 pages, 5018 KiB  
Article
FISH–Flow Cytometry Reveals Microbiome-Wide Changes in Post-Translational Modification and Altered Microbial Abundance Among Children with Inflammatory Bowel Disease
by Mevlut Ulas, Seamus Hussey, Annemarie Broderick, Emer Fitzpatrick, Cara Dunne, Sarah Cooper, Anna Dominik and Billy Bourke
Pathogens 2024, 13(12), 1102; https://doi.org/10.3390/pathogens13121102 - 13 Dec 2024
Viewed by 931
Abstract
Metaproteomic analysis of microbiome post-translation modifications (PTMm) is challenging, and little is known about the effects of inflammation on the bacterial PTM landscape in IBD. Here, we adapted and optimised fluorescence in situ hybridisation–flow cytometry (FISH-FC) to study microbiome-wide tyrosine phosphorylation (p-Tyr) in [...] Read more.
Metaproteomic analysis of microbiome post-translation modifications (PTMm) is challenging, and little is known about the effects of inflammation on the bacterial PTM landscape in IBD. Here, we adapted and optimised fluorescence in situ hybridisation–flow cytometry (FISH-FC) to study microbiome-wide tyrosine phosphorylation (p-Tyr) in children with and without inflammatory bowel disease (IBD). Microbial p-Tyr signal was significantly higher in children with IBD, compared to those without. Faecalibacterium prausnitzii, Bacteroidota, Gammaproteobacteria and Bifidobacteria tended to be more abundant in IBD than in non-IBD control children but there were only minor differences in p-Tyr among these bacterial communities in those with and without IBD. p-Tyr was significantly lower in non-IBD children older than 9 yrs compared with those less than 9 yrs, and the effect was seen in all four bacterial subgroups studied. The opposite trend was seen in patients with IBD. p-Tyr overall is higher in children with IBD but the effects of inflammation on p-Tyr vary according to the bacterial community. The overall microbiome p-Tyr signal changes with age in healthy children. FISH-FC can be used to study the microbiome-wide PTM landscape. Full article
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